About: CC Chemokine Receptor 2 is Protective Against Noise-Induced Hair Cell Death: Studies in CX3CR1(+/GFP) Mice

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About: CC Chemokine Receptor 2 is Protective Against Noise-Induced Hair Cell Death: Studies in CX3CR1(+/GFP) Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CC Chemokine Receptor 2 is Protective Against Noise-Induced Hair Cell Death: Studies in CX3CR1(+/GFP) Mice
Creator	Hirose, Keiko Ransohoff, Richard Sautter, Nathan Shick, Elizabeth Charo, Israel
Source	Medline; PMC
abstract	Acoustic trauma was recently shown to induce an inflammatory response in the ear characterized by rapid entry of macrophages in the spiral ligament. The current study seeks to elucidate the mechanisms involved in summoning macrophages to the cochlear lateral wall and the role macrophages play in noise-induced injury or repair. CCL2 and its primary receptor, CCR2, are the most widely validated effectors of monocyte chemotaxis in vivo. CCL2(−/−) and CCR2(−/−) mice have been used extensively in studies of monocyte activation in neuronal injury. However, the function of CCL2 and CCR2 in the cochlea has not been studied. The present study examines the role of CCL2 and CCR2 in acoustic injury. CCL2(−/−) and CCR2(−/−) mice on a CX3CR1(+/GFP) background were exposed to octave band noise (8–16 kHz) for 2 h to determine the effect of CCL2 and CCR2 on monocyte migration into the cochlea, threshold shift, and cell survival. We found that threshold shift was unchanged in the two knockout mouse strains when compared to the background strain (CX3CR1(+/GFP)). Surprisingly, we found that monocyte migration was also unchanged, despite the absence of CCL2 or CCR2. However, there was a dramatic increase in noise-induced hair cell death in the CCR2(−/−) strain. This observation suggests that CCR2, independent of CCL2, plays a protective role in the cochlea after noise, and neither ligand nor receptor is necessary for monocyte migration. Possible mechanisms of neuroprotection by CCR2 are discussed.
has issue date	2006-10-31(xsd:dateTime)
bibo:doi	10.1007/s10162-006-0051-x
bibo:pmid	17075702
has license	bronze-oa
sha1sum (hex)	0c929ca540bf82c726f7d2875cb3a9dadacbf663
schema:url	https://doi.org/10.1007/s10162-006-0051-x
resource representing a document's title	CC Chemokine Receptor 2 is Protective Against Noise-Induced Hair Cell Death: Studies in CX3CR1(+/GFP) Mice
has PubMed Central identifier	PMC2504633
has PubMed identifier	17075702
schema:publication	Journal of the Association for Research in Otolaryngology
resource representing a document's body	covid:0c929ca540bf82c726f7d2875cb3a9dadacbf663#body_text
is schema:about of	named entity 'summoning' named entity 'study' named entity 'CCR2' named entity 'acoustic' named entity 'However' named entity 'seeks' named entity 'GFP' named entity 'CELL DEATH' named entity 'WAS A' named entity 'MECHANISMS' named entity 'NECESSARY' named entity 'MONOCYTE CHEMOTAXIS' named entity 'MONOCYTE ACTIVATION' named entity 'EXPOSED TO' named entity 'SHIFT' named entity 'EAR' named entity 'CCR2' named entity 'INDUCED' named entity 'CURRENT' named entity 'ITS' named entity 'INVOLVED' named entity 'LIGAND' named entity 'NEUROPROTECTION' named entity 'ENTRY' named entity 'LATERAL WALL' named entity 'NEITHER' named entity 'RECENTLY' named entity 'INDEPENDENT OF' named entity 'RECEPTOR' named entity 'RAPID' named entity 'MACROPHAGES' named entity 'HAIR CELL' named entity 'STUDIES' named entity 'ABSENCE OF' named entity 'PLAY' named entity 'KHZ' named entity 'SPIRAL LIGAMENT' named entity 'COMPARED' named entity 'DETERMINE' named entity 'BAND' named entity 'HAVE' named entity 'CC CHEMOKINE RECEPTOR 2' named entity 'STRAIN' named entity 'PROTECTIVE ROLE' named entity 'MOUSE STRAINS' named entity 'INFLAMMATORY RESPONSE' named entity 'UNCHANGED' named entity 'PRESENT' named entity 'EFFECT' covid:arg/0c929ca540bf82c726f7d2875cb3a9dadacbf663 named entity 'BACKGROUND' named entity 'THRESHOLD' named entity 'VALIDATED' named entity 'CX3CR1' named entity 'STUDIES' named entity 'HAIR CELL' named entity 'NOISE' named entity '288' named entity 'REPAIR' named entity 'ACOUSTIC' named entity 'OBSERVATION' named entity 'USED' named entity 'COCHLEA' named entity 'INCREASE' named entity 'CELL SURVIVAL' named entity 'ROLE' named entity 'STUDY' named entity 'POSSIBLE' named entity 'INJURY' named entity 'IN VIVO' named entity 'CX3CR1' named entity 'ACOUSTIC TRAUMA' named entity 'INDUCE' named entity 'PRIMARY' named entity 'NOISE' named entity 'KNOCKOUT MOUSE' named entity 'MONOCYTE MIGRATION'

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