About: Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity
Creator	Bosch, Berend-Jan Li, Wentao Boons, Geert-Jan Li, Zeshi Lang, Yifei Koerhuis, Danielle De Groot, Raoul Van Der Schaar, Hilde Van Kuppeveld, Frank Huizinga, G Rozemuller, Van Den Burg, Arthur
Source	BioRxiv
abstract	Human coronaviruses OC43 and HKU1 are respiratory pathogen of zoonotic origin that have gained worldwide distribution. OC43 apparently emerged from a bovine coronavirus (BCoV) spill-over. All three viruses attach to 9-O-acetylated sialoglycans via spike protein S with hemagglutinin-esterase HE acting as a receptor-destroying enzyme. In BCoV, an HE lectin domain promotes esterase activity towards clustered substrates. OC43 and HKU1, however, lost HE lectin function as an adaptation to humans. Replaying OC43 evolution, we knocked-out BCoV HE lectin function and performed forced evolution-population dynamics analysis. Loss of HE receptor-binding selected for second-site mutations in S, decreasing S binding affinity by orders of magnitude. Irreversible HE mutations selected for cooperativity in virus swarms with low-affinity S minority variants sustaining propagation of high-affinity majority phenotypes. Salvageable HE mutations induced successive second-site substitutions in both S and HE. Apparently, S and HE are functionally interdependent and co-evolve to optimize the balance between attachment and release. This mechanism of glycan-based receptor usage, entailing a concerted, fine-tuned activity of two envelope protein species, is unique among CoVs, but reminiscent of that of influenza A viruses (IAVs). Apparently, general principles fundamental to virion-sialoglycan interactions prompted convergent evolution of two important groups of human and animal pathogens.
has issue date	2020-04-05(xsd:dateTime)
bibo:doi	10.1101/2020.04.03.003699
has license	biorxiv
sha1sum (hex)	0c8847f9dc0c83bcb8f9f91bc75c82c44e1218c8
schema:url	https://doi.org/10.1101/2020.04.03.003699
resource representing a document's title	Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity
schema:publication	bioRxiv
resource representing a document's body	covid:0c8847f9dc0c83bcb8f9f91bc75c82c44e1218c8#body_text
is schema:about of	named entity 'human' named entity 'hosts' named entity 'performed' named entity 'OC43' named entity 'Orthocoronavirinae' named entity 'socio-economic' named entity 'Severe acute respiratory syndrome' named entity 'China' named entity 'lectin' named entity 'induced' named entity 'zoonotic infection' named entity 'SPECIES' named entity 'POPULATION' named entity 'ESTERASE ACTIVITY' named entity 'CAUSES' named entity 'IDENTICAL' named entity 'HOSTS' named entity 'HUMAN' named entity 'SPREAD' named entity 'FINE' named entity 'CONTAINED' named entity 'LOW' named entity 'CORONAVIRUS' named entity 'ECONOMIC IMPACT' named entity 'DECEMBER' named entity 'FUNCTION' named entity 'OPTIMIZE' named entity 'IRREVERSIBLE' named entity 'IMPORTANT' covid:arg/0c8847f9dc0c83bcb8f9f91bc75c82c44e1218c8 named entity 'full scale' named entity 'The' named entity 'civets' named entity 'Wuhan' named entity 'function' named entity 'mutations' named entity 'Seven' named entity 'mutations' named entity 'emergence' named entity 'Irreversible' named entity 'orders' named entity 'humans' named entity 'infect' named entity 'reminiscent' named entity 'measures' named entity 'fundamental' named entity 'humans' named entity 'horseshoe bats' named entity 'transmission' named entity 'protein' named entity 'transient' named entity 'viruses' named entity 'proteins' named entity 'Wuhan' named entity 'masked palm civets' named entity 'lectin' named entity 'evolution' named entity 'virus' named entity 'receptor' named entity 'dromedary camels' named entity 'bovine coronavirus' named entity 'coronaviruses' named entity 'SARS CoV' named entity 'coronaviruses' named entity 'SARS-CoV' named entity 'horseshoe bats' named entity 'convergent evolution' named entity 'receptor' named entity 'OC43' named entity 'OC43' named entity 'Orthocoronavirinae' named entity 'zoonotic infection' named entity 'binding affinity'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software