About: Coexistence of multiple genotypes of porcine epidemic diarrhea virus with novel mutant S genes in the Hubei Province of China in 2016

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About: Coexistence of multiple genotypes of porcine epidemic diarrhea virus with novel mutant S genes in the Hubei Province of China in 2016 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Coexistence of multiple genotypes of porcine epidemic diarrhea virus with novel mutant S genes in the Hubei Province of China in 2016
Creator	Jin, Xin Ge, Xing-Yi Zeng, Zhe Li, Ting-Ting Peng, Fu-Hu Peng, Gui-Qing Song, Nian-Hua
Source	Medline; PMC
abstract	The emergence of highly virulent porcine epidemic diarrhea virus (PEDV) variants in China caused huge economic losses in 2010. Since then, large-scale sporadic outbreaks of PED caused by PEDV variants have occasionally occurred in China. However, the molecular diversity and epidemiology of PEDV in different provinces has not been completely understood. To determine the molecular diversity of PEDV in the Hubei Province of China, we collected 172 PED samples from 34 farms across the province in 2016 and performed reverse transcription polymerase chain reaction (RT-PCR) by targeting the nucleocapsid (N) gene. Seventy-four samples were found to be PEDV-positive. We further characterized the complete spike (S) glycoprotein genes from the positive samples and found 21 different S genes with amino acid mutations. The PEDV isolates here presented most of the genotypes which were found previously in field isolates in East and South-East Asia, North America, and Europe. Besides the typical Genotypes I and II, the INDEX groups were also found. Importantly, 58 new amino acids mutant sites in the S genes, including 44 sites in S1 and 14 sites in S2, were first described. Our results revealed that the S genes of PEDV showed variation and that diverse genotypes of PEDV coexisted and were responsible for the PED outbreaks in Hubei in 2016. This work highlighted the complexity of the epidemiology of PEDV and emphasized the need for reassessing the efficacy of classic PEDV vaccines against emerging variant strains and developing new vaccines to facilitate the prevention and control of PEDV in fields. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s12250-017-4021-8 and is accessible for authorized users.
has issue date	2017-07-26(xsd:dateTime)
bibo:doi	10.1007/s12250-017-4021-8
bibo:pmid	28755162
has license	bronze-oa
sha1sum (hex)	0c756adaec2279fc7270610fcd44d0850de1240a
schema:url	https://doi.org/10.1007/s12250-017-4021-8
resource representing a document's title	Coexistence of multiple genotypes of porcine epidemic diarrhea virus with novel mutant S genes in the Hubei Province of China in 2016
has PubMed Central identifier	PMC6599178
has PubMed identifier	28755162
schema:publication	Virologica Sinica
resource representing a document's body	covid:0c756adaec2279fc7270610fcd44d0850de1240a#body_text
is schema:about of	named entity 'genes' named entity 'East' named entity 'developing' named entity 'samples' named entity 'farms' named entity 'mutant' named entity 'GENOTYPES' named entity 'COEXISTENCE' named entity 'CAUSED BY' named entity 'EUROPE' named entity 'NUCLEOCAPSID' named entity 'GENES' named entity 'REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION' named entity 'EPIDEMIOLOGY' named entity 'FOUND' named entity 'DIFFERENT' named entity 'PCR' named entity 'VARIANTS' named entity 'DIVERSITY' named entity 'DESCRIBED' named entity 'MUTANT' named entity 'VARIANT' named entity 'CHINA' named entity 'EAST ASIA' covid:arg/0c756adaec2279fc7270610fcd44d0850de1240a named entity 'MULTIPLE' named entity 'SAMPLES' named entity 'AMINO ACID' named entity 'OUR' named entity 'COMPLETE' named entity 'MOLECULAR' named entity 'SOUTH' named entity 'GENE' named entity 'MUTATIONS' named entity 'WORK' named entity '172' named entity 'EFFICACY' named entity 'NEED FOR' named entity 'COMPLEXITY' named entity 'PREVIOUSLY' named entity 'INDEX' named entity 'PED' named entity 'TYPICAL' named entity '28S' named entity 'DEVELOPING' named entity 'DETERMINE' named entity 'COMPLETELY' named entity 'OCCURRED' named entity 'STRAINS' named entity 'VACCINES' named entity 'OCCASIONALLY' named entity 'POSITIVE' named entity 'REVEALED' named entity 'RESULTS' named entity 'PRESENTED' named entity 'SITES' named entity 'ISOLATES' named entity 'SEVENTY-FOUR' named entity 'CHARACTERIZED' named entity 'UNDERSTOOD' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'GENES' named entity 'NOVEL' named entity 'CHINA' named entity 'MUTANT' named entity 'HUBEI PROVINCE' named entity 'AMINO ACIDS' named entity 'PROVINCE' named entity 'RESPONSIBLE' named entity 'OUTBREAKS' named entity 'TARGETING' named entity 'NORTH AMERICA' named entity 'FARMS' named entity 'GLYCOPROTEIN' named entity 'SPORADIC'

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