About: Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice

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About: Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice
Creator	Sun, Yang Xu, Qiang Li, Yan Guo, Wenjie Cui, Jian Liu, Wen Li, Gao Xu, Gao, Jian Qu, Jiao Fan, Ting Or, Qiang
topic	covid:0c1a4ecb085b59c4b5a89467b47a5d75483968d0#this
Source	Elsevier; PMC
abstract	Pneumonia is a common illness that continues to be the major killer of remaining to be a significant source of morbidity and mortality in the patient population. Many microorganisms cause pneumonia, and now concern is turning to the importance of the cause the new therapies for viral pneumonia. In the current study, we report the effect of andrographolide sulfonate, a water-soluble form of andrographolide (trade name: Xi-Yan-Ping Injection), on poly I: C-induced pneumonia. Andrographolide sulfonate was administrated through intraperitoneal injection to mice with poly I: C-induced pneumonia. Recruitment of airway inflammatory cells, alteration of lung histological induced by Poly I: C were significantly ameliorated by andrographolide sulfonate. The protein levels of pro-inflammatory cytokines in bronchoalveolar fluid (BALF) and serum were reduced by andrographolide sulfonate treatment. The levels of MUC5AC and MUC5B in lung tissue were also suppressed. These results reveal that andrographolide sulfate remarkably alleviated pneumonia induced by poly I:C in mice. Moreover, andrographolide sulfonate markedly inhibited the activation of nuclear factor-κB (NF-κB). Taken together, we demonstrated that andrographolide sulfonate ameliorated poly I: C-induced pneumonia in mice, suggesting the possible use of andrographolide sulfonate for virus-induced pneumonia in clinical.
has issue date	2020-08-26(xsd:dateTime)
bibo:doi	10.1016/j.jphs.2020.08.005
has license	els-covid
sha1sum (hex)	0c1a4ecb085b59c4b5a89467b47a5d75483968d0
schema:url	https://doi.org/10.1016/j.jphs.2020.08.005
resource representing a document's title	Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice
has PubMed Central identifier	PMC7448882
schema:publication	J Pharmacol Sci
resource representing a document's body	covid:0c1a4ecb085b59c4b5a89467b47a5d75483968d0#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/0c1a4ecb085b59c4b5a89467b47a5d75483968d0
is schema:about of	named entity 'patient' named entity 'pneumonia' named entity 'mice' named entity 'lung' named entity 'reduced' named entity 'NF-κB' named entity 'induced' named entity 'inhibited' named entity 'poly' covid:arg/0c1a4ecb085b59c4b5a89467b47a5d75483968d0 named entity 'morbidity' named entity 'NF-κB' named entity 'sulfonate' named entity 'Injection' named entity 'mice' named entity 'sulfonate' named entity 'induced' named entity 'histological' named entity 'alteration' named entity 'poly' named entity 'water-soluble' named entity 'significant source' named entity 'andrographolide' named entity 'microorganisms' named entity 'serum' named entity 'pneumonia' named entity 'sulfonate' named entity 'histological' named entity 'andrographolide' named entity 'sulfonate' named entity 'lung tissue' named entity 'mice' named entity 'MUC5AC' named entity 'NF-κB' named entity 'sulfate' named entity 'Andrographolide' named entity 'Th1/Th17 response' named entity 'inflammasomes' named entity 'inflammation' named entity 'MUC5AC' named entity 'SARS-CoV-2' named entity 'IL-1β' named entity 'dose-dependent manner' named entity 'Beverly, MA' named entity 'NF-κB' named entity 'MUC5B' named entity 'lungs' named entity 'volume fraction' named entity 'andrographolide' named entity 'BALF' named entity 'mucus hypersecretion' named entity 'NF-κB' named entity 'pneumonia' named entity 'histological' named entity 'protein' named entity 'MUC5AC' named entity 'andrographolide' named entity 'MUC1' named entity 'IL-1β' named entity 'idiopathic pulmonary fibrosis' named entity 'coronavirus 2' named entity 'andrographolide' named entity 'phosphorylation' named entity 'viruses' named entity 'Poly I:C' named entity 'morbidity' named entity 'Middle East respiratory syndrome coronavirus' named entity 'andrographolide' named entity 'BALF' named entity 'SARS-CoV'

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