About: From mice to women: the conundrum of immunity to infection during pregnancy

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: From mice to women: the conundrum of immunity to infection during pregnancy Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	From mice to women: the conundrum of immunity to infection during pregnancy
Creator	Krishnan, Lakshmi Nguyen, Tina Mccomb, Scott
Source	Elsevier; Medline; PMC
abstract	Resistance to infection is the ability of the host to evoke a strong immune response sufficient to eliminate the infectious agent. In contrast, maternal tolerance to the fetus necessitates careful regulation of immune responses. Successful pregnancy requires the maternal host to effectively balance the opposing processes of maternal immune reactivity and tolerance to the fetus. However, this balance can be perturbed by infections which are recognized as the major cause of adverse pregnancy outcome including pre-term labor. Select pathogens also pose a serious threat of severe maternal illness. These include intracellular and chronic pathogens that have evolved immune evasive strategies. Murine models of intracellular bacteria and parasites that mimic pathogenesis of infection in humans have been developed. While human epidemiological studies provide insight into maternal immunity to infection, experimental infection in pregnant mice is a vital tool to unravel the complex molecular mechanisms of placental infection, congenital transmission and maternal illness. We will provide a comprehensive review of the pathogenesis of several infection models in pregnant mice and their clinical relevance. These models have revealed the immunological function of the placenta in responding to, and resisting infection. Murine feto-placental infection provides an effective way to evaluate new intervention strategies for managing infections during pregnancy, adverse fetal outcome and long-term effects on the offspring and mother.
has issue date	2013-03-01(xsd:dateTime)
bibo:doi	10.1016/j.jri.2012.10.015
bibo:pmid	23432873
has license	green-oa
sha1sum (hex)	0c12707e3172995780a54f27d7aff92e06c70a5e
schema:url	https://doi.org/10.1016/j.jri.2012.10.015
resource representing a document's title	From mice to women: the conundrum of immunity to infection during pregnancy
has PubMed Central identifier	PMC3748615
has PubMed identifier	23432873
schema:publication	Journal of Reproductive Immunology
resource representing a document's body	covid:0c12707e3172995780a54f27d7aff92e06c70a5e#body_text
is schema:about of	named entity 'MICE' named entity 'intracellular' named entity 'tolerance' named entity 'infection' named entity 'parasites' named entity 'Murine' named entity 'congenital' named entity 'FUNCTION' named entity 'RESISTING' named entity 'INTRACELLULAR' named entity 'STRATEGIES' named entity 'MANAGING' named entity 'INTERVENTION STRATEGIES' named entity 'EVALUATE' covid:arg/0c12707e3172995780a54f27d7aff92e06c70a5e named entity 'SUCCESSFUL' named entity 'CONTRAST' named entity 'BALANCE' named entity 'MODELS' named entity 'EVOLVED' named entity 'PRE-TERM' named entity 'PREGNANCY' named entity 'HAVE' named entity 'OFFSPRING' named entity 'IMMUNE RESPONSE' named entity 'VITAL' named entity 'TOOL' named entity 'EFFECTIVE' named entity 'IMMUNOLOGICAL' named entity 'DURING PREGNANCY' named entity 'SUFFICIENT' named entity 'IMMUNITY' named entity 'STRONG' named entity 'INCLUDING' named entity 'PROVIDE' named entity 'EXPERIMENTAL INFECTION' named entity 'MATERNAL' named entity 'ADVERSE PREGNANCY OUTCOME' named entity 'WOMEN' named entity 'INFECTION' named entity 'THEIR' named entity 'WAY' named entity 'FETAL OUTCOME' named entity 'COMPLEX' named entity 'HUMANS' named entity 'PLACENTAL INFECTION' named entity 'INCLUDE' named entity 'INSIGHT' named entity 'INFECTION' named entity 'BACTERIA ' named entity 'MICE' named entity 'MOLECULAR' named entity 'MATERNAL ILLNESS' named entity 'LONG-TERM EFFECTS' named entity 'REVEALED' named entity 'MURINE' named entity 'SELECT' named entity 'REVIEW OF' named entity 'DURING PREGNANCY' named entity 'SEVERE' named entity 'THREAT' named entity 'CAUSE' named entity 'PREGNANT' named entity 'MAJOR' named entity 'IMMUNE' named entity 'IMMUNITY' named entity 'THESE' named entity 'MOTHER' named entity 'PLACENTA' named entity 'ABILITY' named entity 'IS A' named entity 'INFECTIONS' named entity 'NEW' named entity 'TOLERANCE' named entity 'PROCESSES' named entity 'CHRONIC' named entity 'CLINICAL RELEVANCE' named entity 'MECHANISMS' named entity 'PATHOGENESIS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software