About: Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV)

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About: Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV)
Creator	Chong, Youhoon Yoon, Hyunjun Kim, Mi Park, Hye Dae Lee, Sung
topic	covid:0bfad70da896a173ccfb55c8809a3ef97d1ec8ef#this
Source	Medline; PMC
abstract	Aryl diketoacid (ADK) is well known for antiviral activity which can be enhanced by introduction of an aromatic arylmethyl substituent. A natural flavonoid quercetin has a 3,5-dihydroxychromone pharmacophore which is in bioisosteric relationship with the 1,3-diketoacid moiety of the ADK. Thus, it was of our interest to test the antiviral activity of the quercetin derivatives with an arylmethyl group attached. In this study, we prepared a series of the 7-O-arylmethylquercetin derivatives with various aromatic substituents and evaluated their antiviral activity against the SARS-associated coronavirus (SARS-CoV, SCV) as well as hepatitis C virus (HCV). Single difference in the aromatic substituent fine-tuned the biological activity of the 7-O-arylmethylquercetin derivatives to result in two different classes of derivatives selectively active against SCV and HCV.
has issue date	2012-02-02(xsd:dateTime)
bibo:doi	10.1007/s12272-012-0108-9
bibo:pmid	22297745
has license	no-cc
sha1sum (hex)	0bfad70da896a173ccfb55c8809a3ef97d1ec8ef
schema:url	https://doi.org/10.1007/s12272-012-0108-9
resource representing a document's title	Synthesis and antiviral evaluation of 7-O-arylmethylquercetin derivatives against SARS-associated coronavirus (SCV) and hepatitis C virus (HCV)
has PubMed Central identifier	PMC7090976
has PubMed identifier	22297745
schema:publication	Arch Pharm Res
resource representing a document's body	covid:0bfad70da896a173ccfb55c8809a3ef97d1ec8ef#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/0bfad70da896a173ccfb55c8809a3ef97d1ec8ef
is schema:about of	named entity 'SCV' named entity 'SARS-associated coronavirus' named entity 'SARS-CoV' named entity 'enhanced' named entity 'STUDY' named entity 'INTRODUCTION' named entity 'DIFFERENCE' named entity 'RELATIONSHIP' named entity 'FINE' named entity 'MOIETY' named entity 'OUR' named entity 'KNOWN' named entity 'SARS-ASSOCIATED CORONAVIRUS' named entity 'HEPATITIS C VIRUS' named entity 'EVALUATED' named entity 'BIOLOGICAL ACTIVITY' named entity 'THEIR' named entity 'CLASSES' named entity 'AROMATIC' named entity 'INTEREST' named entity 'EVALUATION' named entity 'ANTIVIRAL' named entity '2C5' named entity 'VARIOUS' named entity 'ENHANCED' named entity 'SUBSTITUENT' named entity 'ACTIVE' named entity 'ANTIVIRAL ACTIVITY' named entity 'QUERCETIN' named entity 'FLAVONOID' named entity 'SCV' named entity 'PHARMACOPHORE' named entity 'SERIES' named entity 'TO TEST' named entity 'HEPATITIS C VIRUS' named entity 'RESULT' named entity 'SARS-ASSOCIATED CORONAVIRUS' named entity 'ADK' named entity 'SINGLE' named entity 'DIFFERENT' named entity 'SYNTHESIS' named entity 'NATURAL' named entity 'PREPARED' named entity 'GROUP' named entity 'HCV' named entity 'ATTACHED' covid:arg/0bfad70da896a173ccfb55c8809a3ef97d1ec8ef named entity 'natural' named entity 'substituents' named entity 'derivatives' named entity 'ADK' named entity 'moiety' named entity 'prepared' named entity 'study' named entity 'selectively' named entity 'antiviral' named entity '3,5' named entity 'flavonoid' named entity 'SARS-associated coronavirus' named entity 'antiviral activity' named entity 'substituent' named entity 'pharmacophore' named entity 'aromatic' named entity 'bioisosteric' named entity 'moiety' named entity 'quercetin' named entity 'antiviral activity' named entity 'SARS' named entity 'SCV' named entity 'DMSO' named entity 'cytostatic' named entity 'm/z' named entity '2.0' named entity '8.5' named entity 'herpes simplex virus type 1'

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