About: Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease

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About: Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease
Creator	Haspel, Martin Knobler, Robert Oldstone, Michael
Source	PMC
abstract	Mouse hepatitis virus (JHM strain) type 4 induces acute encephalitis followed by death in many strains of laboratory mice. Immunohistochemical study in vivo and analysis of mouse neuronal cells in vitro both indicate that the target cells in this infection is the neuron. Further, examination of several inbred mouse strains and neuronal cells from them shows that disease expression is controlled by a single autosomal gene action at the level of the neuronal cell. Susceptibility is dominant but not H-2 linked. However, cultured neuronal cells and macrophages from SJL/J mice, which are resistant to this infection, fail to make significant amounts of infectious virus after an appropriate viral inoculation. Apparently the defect is not at the level of the virus-cell receptor, because these cells, in part, express viral antigens.
has issue date	1981-04-01(xsd:dateTime)
bibo:pmid	6265583
has license	cc-by-nc-sa
sha1sum (hex)	0b90f302993b075229dbe5f9bc03a180b2e2632f
resource representing a document's title	Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease
has PubMed Central identifier	PMC2186133
has PubMed identifier	6265583
schema:publication	J Exp Med
resource representing a document's body	covid:0b90f302993b075229dbe5f9bc03a180b2e2632f#body_text
is schema:about of	named entity 'Disease' named entity 'TYPE 4' named entity 'CENTRAL' named entity 'SUSCEPTIBLE' named entity 'VIRUS TYPE' named entity 'CENTRAL NERVOUS SYSTEM DISEASE' named entity 'TYPE 4' named entity 'MOUSE HEPATITIS VIRUS' named entity 'GENETIC CONTROL' named entity 'FATAL' named entity 'STRAIN' named entity 'NEURON' named entity 'INDUCED' named entity 'MURINE' named entity 'Site' named entity 'Neuron' named entity 'gene' named entity 'autosomal recessive gene' named entity 'virus' named entity 'virus' named entity 'mice' named entity 'BALB' named entity 'neuronal cell' named entity 'phagocytize' named entity 'mortality rate' named entity 'Virus' named entity 'viral antigens' named entity 'mice' named entity 'neuronal cells' named entity 'neurons' named entity 'inbred strains' named entity 'neurons' named entity 'mice' named entity 'Immunohistochemical' named entity 'recombinant' named entity 'encephalomyocarditis virus' named entity 'oligodendrocytes' named entity 'F1 hybrids' named entity 'macrophages' named entity 'virus' named entity 'receptor' named entity 'mice' named entity 'BALB' named entity 'BALB' named entity 'mice' named entity 'recessive' named entity 'immunization' named entity 'virus' named entity 'C57BL/6J' named entity 'Neuronal' named entity 'antigens' named entity 'Mouse hepatitis virus' named entity 'macrophages' named entity 'WEHI' named entity 'mice' named entity 'Virus' named entity 'virus' named entity 'glycerol' named entity 'mice' named entity 'BALB' named entity 'phosphate-buffered saline' named entity 'brain tissue' named entity 'neuronal cells' named entity 'thioglycollate broth' named entity 'mice' named entity 'mice' named entity 'major histocompatibility' named entity 'BALB' named entity 'neuronal cells' named entity 'antigens' named entity 'F1 hybrids' named entity 'virus' named entity 'degenerative diseases' named entity 'mice' named entity 'Virus' named entity 'viral antigens' named entity 'neurons' named entity 'infection' named entity 'mice' named entity 'backcross' named entity 'complement'

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