About: T(FH) cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1

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About: T(FH) cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	T(FH) cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1
Creator	Jagodzinski, Linda Allam, Atef Casares, Sofia Kim, Jiae Majji, Sai Merbah, Melanie Peachman, Kristina Rao, Mangala Ratto-Kim, Silvia Wijayalath, Wathsala Kim, Jerome Michael, Nelson Alving, Carl
Source	PMC
abstract	CD4(+) T follicular helper cells (T(FH)) in germinal centers are required for maturation of B-cells. While the role of T(FH)-cells has been studied in blood and lymph nodes of HIV-1 infected individuals, its role in the mucosal tissues has not been investigated. We show that the gut and female reproductive tract (FRT) of humanized DRAG mice have a high level of human lymphocytes and a high frequency of T(FH) (CXCR5(+)PD-1(++)) and precursor-T(FH) (CXCR5(+)PD-1(+)) cells. The majority of T(FH)-cells expressed CCR5 and CXCR3 and are the most permissive to HIV-1 infection. A single low-dose intravaginal HIV-1 challenge of humanized DRAG mice results in 100% infectivity with accumulation of T(FH)-cells mainly in the Peyer’s patches and FRT. The novel finding of T(FH)-cells in the FRT may contribute to the high susceptibility of DRAG mice to HIV-1 infection. This mouse model thus provides new opportunities to study T(FH)-cells and to evaluate HIV-1 vaccines.
has issue date	2015-06-02(xsd:dateTime)
bibo:doi	10.1038/srep10443
bibo:pmid	26034905
has license	cc-by
sha1sum (hex)	0b7d50ddfae18226d4a66c578d9235d872c85056
schema:url	https://doi.org/10.1038/srep10443
resource representing a document's title	T(FH) cells accumulate in mucosal tissues of humanized-DRAG mice and are highly permissive to HIV-1
has PubMed Central identifier	PMC4451806
has PubMed identifier	26034905
schema:publication	Sci Rep
resource representing a document's body	covid:0b7d50ddfae18226d4a66c578d9235d872c85056#body_text
is schema:about of	named entity 'PD-1' named entity 'susceptibility' named entity 'cells' named entity 'human' named entity 'model' named entity 'PD-1' named entity 'permissive' covid:arg/0b7d50ddfae18226d4a66c578d9235d872c85056 named entity 'While' named entity 'mouse' named entity 'lymphocytes' named entity 'vaccines' named entity 'CXCR5' named entity 'germinal centers' named entity 'mice' named entity 'HIV-1' named entity 'mucosal' named entity 'CCR5' named entity 'PD-1' named entity 'CXCR5' named entity 'CD4 +' named entity 'IgG antibodies' named entity 'FRT' named entity 'IL-21' named entity 'anti-PD-1' named entity 'CXCR5' named entity 'BCL-6' named entity 'infection' named entity 'BCL-6' named entity 'CD4 +' named entity 'PD-1' named entity 'CD4 T cell' named entity 'PD-1' named entity 'HIV-1' named entity 'HIV-1 infection' named entity 'fluorescent' named entity 'CD4 +' named entity 'HIV-1 infection' named entity 'CD4 +' named entity 'CXCR3' named entity 'gut associated lymphoid tissue' named entity 'CCR5' named entity 'HIV-1' named entity 'hysterectomy' named entity 'Scientific RepoRts' named entity 'intracellular' named entity 'supernatants' named entity 'PD-1' named entity 'Flow cytometry' named entity 'inoculation' named entity 'CD4 +' named entity 'cell cultures' named entity 'PD-1' named entity 'memory T cells' named entity 'IEL' named entity 'FRT' named entity 'CD8 +' named entity 'ICOS' named entity 'ICOS' named entity 'HIV-1 infection' named entity 'BD Biosciences' named entity 'Institutional Review Board' named entity 'SIV' named entity 'FRT' named entity 'HIV-1' named entity 'CD8 +' named entity 'CXCR5' named entity 'mesenteric lymph nodes' named entity 'CD4 +'

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