About: Validation of age, PaO(2)/FlO(2) and plateau pressure score in Korean patients with acute respiratory distress syndrome: a retrospective cohort study

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About: Validation of age, PaO(2)/FlO(2) and plateau pressure score in Korean patients with acute respiratory distress syndrome: a retrospective cohort study Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Validation of age, PaO(2)/FlO(2) and plateau pressure score in Korean patients with acute respiratory distress syndrome: a retrospective cohort study
Creator	Lee, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Yoo, Chul-Gyu Choi, Sun Kim, Young Park, Young Han, Sung Hwang, Hyeontaek
source	PMC
abstract	BACKGROUND: A predictive scoring system for acute respiratory distress syndrome (ARDS) patients, which incorporates age, PaO(2)/FlO(2), and plateau pressure, APPS, was developed recently. It was validated externally in a Caucasian population but has not been studied in Asian populations. The aim of this study was to validate APPS in Korean ARDS patients. METHODS: We retrospectively reviewed the medical records of patients who were diagnosed with ARDS using the Berlin criteria and admitted to the medical ICU at Seoul National University Hospital from January 2015 to December 2016. The validation of the APPS was performed by evaluating its calibration and predictive accuracy. Its calibration was plotted and quantified using the Hosmer–Lemeshow test. Its predictive accuracy was assessed by calculating the area under the receiver operating characteristics (AUC–ROC) curve. RESULTS: A total of 116 patients were analyzed, 32 of whom survived. Of the 116 patients, 11 (9.5%) were classified as APPS grade 1 (score 3–4), 88 (75.9%) as grade 2 (score 5–7) and 17 (14.6%) as grade 3 (score 8–9). In-hospital mortality was 27.3% for grade 1, 73.9% for grade 2 and 94.1% for grade 3 (P for trend < 0.001). The APPS was well calibrated (Hosmer–Lemeshow test, P = 0.578) and its predictive accuracy was acceptable (AUC–ROC 0.704, 95% confidence interval 0.599–0.809). CONCLUSIONS: The APPS predicted in-hospital mortality in Korean patients with ARDS with similar power to its application in a Western population and with acceptable predictive accuracy. TRIAL REGISTRATION: Retrospectively registered.
has issue date	2020-04-22(xsd:dateTime)
bibo:doi	10.1186/s12931-020-01357-5
bibo:pmid	32321513
has license	cc-by
sha1sum (hex)	0b641b3076caebe2a9d3b719d7ffecedd5c60f94
schema:url	https://doi.org/10.1186/s12931-020-01357-5
resource representing a document's title	Validation of age, PaO(2)/FlO(2) and plateau pressure score in Korean patients with acute respiratory distress syndrome: a retrospective cohort study
has PubMed Central identifier	PMC7178575
has PubMed identifier	32321513
schema:publication	Respir Res
resource representing a document's body	covid:0b641b3076caebe2a9d3b719d7ffecedd5c60f94#body_text
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