About: Interferon and Interferon-Induced Chemokine Expression Is Associated with Control of Acute Viremia in West Nile Virus-Infected Blood Donors

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About: Interferon and Interferon-Induced Chemokine Expression Is Associated with Control of Acute Viremia in West Nile Virus-Infected Blood Donors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon and Interferon-Induced Chemokine Expression Is Associated with Control of Acute Viremia in West Nile Virus-Infected Blood Donors
Creator	Danesh, Ali Busch, Michael Kelvin, David Cameron, Mark Lanciotti, Robert Lanteri, Marion Norris, Philip Persad, Desmond Prince, Harry Tobler, Leslie
Source	PMC
abstract	To understand early host responses controlling West Nile virus (WNV) infection, acutely viremic blood donors, identified by nucleic acid amplification testing, were enrolled and monitored for RNA-clearance and WNV-specific IgM and IgG antibodies. Viral load and chemokine and cytokine assays were performed on serial samples from donors whose index and first follow-up samples tested negative for IgM. A total of 84% of the specimens obtained from viremic donors before IgM/IgG seroconversion demonstrated a decreasing viral load. Levels of interferon (IFN)-α ere significantly increased before IgM seroconversion, relative to those in control specimens. CXCL10 and CCL2 were significantly elevated in donor specimens obtained before IgM seroconversion, compared with those obtained after IgM seroconversion. These findings suggest that IFN-mediated innate immunity plays a key role in initial control of WNV replication.
has issue date	2008-10-01(xsd:dateTime)
bibo:doi	10.1086/591466
bibo:pmid	18729779
has license	no-cc
sha1sum (hex)	0aecfe891a229742990165e93c22334d7f05c6d5
schema:url	https://doi.org/10.1086/591466
resource representing a document's title	Interferon and Interferon-Induced Chemokine Expression Is Associated with Control of Acute Viremia in West Nile Virus-Infected Blood Donors
has PubMed Central identifier	PMC7202400
has PubMed identifier	18729779
schema:publication	J Infect Dis
resource representing a document's body	covid:0aecfe891a229742990165e93c22334d7f05c6d5#body_text
is schema:about of	named entity 'immunity' named entity 'total' named entity 'WNV' named entity 'OBTAINED' named entity 'DONOR' named entity 'cytokine' named entity 'IgM' named entity 'samples' named entity 'CCL2' named entity 'early' named entity 'assays' named entity 'acutely' named entity 'WNV' named entity 'negative' named entity 'WNV' named entity 'Viral load' named entity 'seroconversion' named entity 'IgM' named entity 'IgM' named entity 'IgG antibodies' named entity 'West Nile virus' named entity 'blood donors' named entity 'Interferon' named entity 'Chemokine' named entity 'Blood Donors' named entity 'seroconversion' named entity 'CCL2' named entity 'blood donors' named entity 'WNV' named entity 'seroconversion' named entity 'CXCL9' named entity 'seroconversion' named entity 'monocyte chemoattractant protein-1' named entity 'CXCL10' named entity 'BD Biosciences' named entity 'cDNA' named entity 'interferon' named entity 'arboviral' named entity 'IgM' named entity 'RNA' named entity 'neuroprotective' named entity 'WNV' named entity 'CXCL9' named entity 'proinflammatory' named entity 'Serological testing' named entity 'follow-up' named entity 'IgM' named entity 'viremic' named entity 'encephalitis' named entity 'titer' named entity 'IFN' named entity 'chemokine' named entity 'reverse transcribed' named entity 'CXCL10' named entity 'WNV' named entity 'CCL2' named entity 'IgM' named entity 'downregulation' named entity 'PRNT' named entity 'follow-up' named entity 'virus' named entity 'CXCL10' named entity 'humoral' named entity 'seroconversion' named entity 'IgM' named entity 'inflammation' named entity 'follow-up' named entity 'VLs' named entity 'monokine' named entity 'Viral load' named entity 'VLs' named entity 'IgG antibody'

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