About: Clinical Characteristics of 46 Pregnant Women with a SARS-CoV-2 Infection in Washington State

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical Characteristics of 46 Pregnant Women with a SARS-CoV-2 Infection in Washington State
Creator	Ba, Mccartney, Stephen Blain, Michela Delaney, Shani Deutsch, Gail Kretzer, Nicole Lacourse, Sylvia Lokken, Erica Ma, Kimberly Waldorf, Kristina Kachikis, Alisa Huebner, Emily Ba, Stephen Barnhart, Nena Bw, Paek Cr, Kline Em, Huebner Erickson, Anne Walker, Christie Hwang, Joseph Jk, Hwang Js, Sheng Kk, Ma Kline, Carolyn Mccartney, Munson, J Munson, Jeff Paek, Bettina Rah, Jasmine Resnick, Rebecca Retzlaff, Kristin Sa, Mccartney Sheng, Jessica State, Washington Thomas, Chad Vanderhoeven, Jeroen Washington, Washington
Source	Elsevier; Medline; PMC
abstract	Abstract Background The impact of the coronavirus disease 2019 (Covid-19) on pregnant women is incompletely understood, but early data from case series suggest a variable course of illness from asymptomatic or mild disease to maternal death. It is unclear whether pregnant women manifest enhanced disease similar to influenza viral infection or whether specific risk factors might predispose to severe disease. Objective To describe maternal disease and obstetrical outcomes associated with Covid-19 disease in pregnancy to rapidly inform clinical care. Study Design Retrospective study of pregnant patients with a laboratory-confirmed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection from six hospital systems in Washington State between January 21, 2020 and April 17, 2020. Demographics, medical and obstetric history, and Covid-19 encounter data were abstracted from medical records. Results A total of 46 pregnant patients with a SARS-CoV-2 infection were identified from hospital systems capturing 40% of births in Washington State. Nearly all pregnant individuals with a SARS-CoV-2 infection were symptomatic (93.5%, n=43) and the majority were in their second or third trimester (43.5%, n=20 and 50.0%, n=23, respectively). Symptoms resolved in a median of 24 days (interquartile range 13-37). Seven women were hospitalized (16%) including one admitted to the intensive care unit. Six cases (15%) were categorized as severe Covid-19 disease with nearly all patients being either overweight or obese prior to pregnancy, asthma or other co-morbidities. Eight deliveries occurred during the study period, including a preterm birth at 33 weeks to improve pulmonary status in a woman with Class III obesity. One stillbirth occurred of unknown etiology. Conclusions Nearly 15% of pregnant patients developed severe Covid-19, which occurred primarily in overweight or obese women with underlying conditions. Obesity and Covid-19 may synergistically increase risk for a medically-indicated preterm birth to improve maternal pulmonary status in late pregnancy. Collectively, these findings support categorizing pregnant patients as a higher risk group, particularly for those with chronic co-morbidities.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.1016/j.ajog.2020.05.031
bibo:pmid	32439389
has license	els-covid
sha1sum (hex)	0ad11c8de3536bfb54f1201d5829fe78700bd72d
schema:url	https://doi.org/10.1016/j.ajog.2020.05.031
resource representing a document's title	Clinical Characteristics of 46 Pregnant Women with a SARS-CoV-2 Infection in Washington State
has PubMed Central identifier	PMC7234933
has PubMed identifier	32439389
schema:publication	Am J Obstet Gynecol
resource representing a document's body	covid:0ad11c8de3536bfb54f1201d5829fe78700bd72d#body_text
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