About: Summary Endogenous interferon (IFN) made by the newborn piglet in response to enteric coronavirus TGEV (transmissible gastroenteritis virus) infection was identified as leukocytic IFN (IFN-α). Indeed, the antiviral activity found in the serum and in the urine of infected piglets displayed the same main biological and antigenic properties as the IFN induced in influenza-infected pig leukocytes. It is therefore concluded that most, if not all, circulating IFN activity must be derived from lymphoid cells. Moreover, it was shown that a high degree of antigenic homology exists between porcine and human IFN-α: antibodies to HuIFN-α could efficiently neutralize PorIFN-α, and they were used for its purification by immunoaffinity.   Goto Sponge  NotDistinct  Permalink

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  • Summary Endogenous interferon (IFN) made by the newborn piglet in response to enteric coronavirus TGEV (transmissible gastroenteritis virus) infection was identified as leukocytic IFN (IFN-α). Indeed, the antiviral activity found in the serum and in the urine of infected piglets displayed the same main biological and antigenic properties as the IFN induced in influenza-infected pig leukocytes. It is therefore concluded that most, if not all, circulating IFN activity must be derived from lymphoid cells. Moreover, it was shown that a high degree of antigenic homology exists between porcine and human IFN-α: antibodies to HuIFN-α could efficiently neutralize PorIFN-α, and they were used for its purification by immunoaffinity.
Subject
  • Immune system
  • Cytokines
  • Antivirals
  • Evolutionary biology
  • Pork
  • Taxa named by Carl Linnaeus
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