About: Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19

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About: Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19
Creator	Liu, Fang Zhou, Xiang Li, Lin Luo, Ding Wu, Juan Li, Bixi Song, Xiaoyang Xu, Mengda Zhu, Yusi
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: The inflammatory response plays a critical role in coronavirus disease 2019 (COVID-19), and inflammatory cytokine storm increases the severity of COVID-19. OBJECTIVE: To investigate the ability of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin (PCT) to predict mild and severe cases of COVID-19. STUDY DESIGN: This retrospective cohort study included 140 patients diagnosed with COVID-19 from January 18, 2020, to March 12, 2020. The study population was divided into two groups according to disease severity: a mild group (MG) (n = 107) and a severe group (SG) (n = 33). Data on demographic characteristics, baseline clinical characteristics, and the levels of IL-6, CRP, and PCT on admission were collected. RESULTS: Among the 140 patients, the levels of IL-6, CRP, and PCT increased in 95 (67.9 %), 91 (65.0 %), and 8 (5.7 %) patients on admission, respectively. The proportion of patients with increased IL-6, CRP, and PCT levels was significantly higher in the SG than in the MG. Cox proportional hazard model showed that IL-6 and CRP could be used as independent factors to predict the severity of COVID-19. Furthermore, patients with IL-6 > 32.1 pg/mL or CRP > 41.8 mg/L were more likely to have severe complications. CONCLUSION: The serum levels of IL-6 and CRP can effectively assess disease severity and predict outcome in patients with COVID-19.
has issue date	2020-04-14(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2020.104370
bibo:pmid	32344321
has license	no-cc
sha1sum (hex)	0a765029b393edafe3308b30dbea068e84a727f4
schema:url	https://doi.org/10.1016/j.jcv.2020.104370
resource representing a document's title	Prognostic value of interleukin-6, C-reactive protein, and procalcitonin in patients with COVID-19
has PubMed Central identifier	PMC7194648
has PubMed identifier	32344321
schema:publication	J Clin Virol
resource representing a document's body	covid:0a765029b393edafe3308b30dbea068e84a727f4#body_text
is schema:about of	named entity 'severe' named entity 'COVID-19' named entity 'disease' named entity 'levels' named entity 'patients' named entity 'C-reactive protein' named entity 'COLLECTED' named entity 'PROPORTION' named entity 'SEVERE' named entity 'DISEASE SEVERITY' named entity 'PCT' named entity 'Data' named entity 'group' named entity 'PCT' named entity 'proportion' named entity 'patients' named entity 'admission' named entity 'levels' named entity 'groups' named entity 'admission' named entity 'IL-6' named entity 'demographic characteristics' named entity 'IL-6' named entity 'IL-6' named entity 'study population' named entity 'COVID-19' named entity 'lung' named entity 'RT-PCR' named entity 'China' named entity 'interleukin-6' named entity 'Wuhan' named entity 'fever' named entity 'comorbidities' named entity 'hematological diseases' named entity 'inflammatory factors' named entity 'sensitivity, specificity' named entity 'CRP' named entity 'respiratory diseases' named entity 'CRP' named entity 'cytokine storm' named entity 'cough' named entity 'COVID-19' named entity 'multiple organ dysfunction' named entity 'clinical symptoms' named entity 'cell signaling' named entity 'Mann-Whitney' named entity 'inflammation' named entity 'shortness of breath' named entity 'CRP' named entity 'Li Lanjuan' named entity 'muscle soreness' named entity 'oropharyngeal' named entity 'CRP' named entity 'fasting' named entity 'proinflammatory' named entity 'World Health Organization' named entity 'COVID-19' named entity 'demographic characteristics' named entity 'sample size' named entity 'CRP' named entity 'cytokine' named entity 'Venous blood' named entity 'Coronavirus disease 2019' named entity 'IL-6' named entity 'Body temperature' named entity 'serological' named entity 'laboratory tests' named entity 'bacterial infections' named entity 'CRP' named entity 'viral infections' named entity 'Demographic characteristics' named entity 'IL-6' named entity 'public health emergency of international concern'

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