About: Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist

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About: Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist
Creator	Christopher-Hennings, J Chen, Z Fang, Y Guan, X Lawson, S Nelson, E Sun, Z Zhou, X
Source	Elsevier; Medline; PMC
abstract	Abstract The porcine reproductive and respiratory syndrome virus nsp1 is predicted to be auto-cleaved from the replicase polyprotein into nsp1α and nsp1β subunits. In infected cells, we detected the actual existence of nsp1α and nsp1β. Cleavage sites between nsp1α/nsp1β and nsp1β/nsp2 were identified by protein microsequencing analysis. Time course study showed that nsp1α and nsp1β mainly localize into the cell nucleus after 10 h post infection. Further analysis revealed that both proteins dramatically inhibited IFN-β expression. The nsp1β was observed to significantly inhibit expression from an interferon-stimulated response element promoter after Sendai virus infection or interferon treatment. It was further determined to inhibit nuclear translocation of STAT1 in the JAK–STAT signaling pathway. These results demonstrated that nsp1β has ability to inhibit both interferon synthesis and signaling, while nsp1α alone strongly inhibits interferon synthesis. These findings provide important insights into mechanisms of nsp1 in PRRSV pathogenesis and its impact in vaccine development.
has issue date	2010-03-01(xsd:dateTime)
bibo:doi	10.1016/j.virol.2009.11.033
bibo:pmid	20006994
has license	els-covid
sha1sum (hex)	0a62c80536aac29f30a65d03070fe79f9e8705c5
schema:url	https://doi.org/10.1016/j.virol.2009.11.033
resource representing a document's title	Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist
has PubMed Central identifier	PMC7111964
has PubMed identifier	20006994
schema:publication	Virology
resource representing a document's body	covid:0a62c80536aac29f30a65d03070fe79f9e8705c5#body_text
is schema:about of	named entity 'inhibit' named entity 'infection' named entity 'infection' named entity 'interferon' named entity 'replicase' named entity 'cells' named entity 'virus' named entity 'POST' named entity 'EXPRESSION' named entity 'DETECTED' named entity 'JAK-STAT SIGNALING PATHWAY' named entity 'IDENTIFIED BY' named entity 'TO INHIBIT' named entity 'MECHANISMS' named entity 'ITS' named entity 'INHIBITED' named entity 'PROTEIN ' named entity 'NUCLEAR TRANSLOCATION' named entity 'PREDICTED' named entity 'CELL NUCLEUS' named entity 'PATHOGENESIS' named entity 'CLEAVED' named entity 'STUDY' named entity 'RESULTS' named entity 'INFECTED' named entity 'MICROSEQUENCING' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'SENDAI VIRUS INFECTION' named entity 'AUTO' named entity 'PROTEINS' named entity 'SITES' named entity 'PROVIDE' named entity 'IFN' named entity 'PROMOTER' named entity 'IMPORTANT' named entity 'OBSERVED' named entity 'ACTUAL' named entity 'INTERFERON-STIMULATED RESPONSE ELEMENT' named entity 'TIME COURSE' named entity 'THESE' named entity 'INSIGHTS' named entity 'ANTAGONIST' named entity 'IDENTIFICATION' named entity 'INFECTED' named entity 'DETERMINED' named entity 'REPLICASE' named entity 'AUTO' named entity 'CELLS' named entity 'FUNCTION' named entity 'PROTEIN ' named entity 'INTERFERON ' named entity 'PRODUCTS' named entity 'SYNTHESIS' named entity 'CLEAVAGE' named entity 'TREATMENT' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'CLEAVAGE' named entity 'FINDINGS' named entity 'REVEALED' named entity 'LOCALIZE' named entity 'ANALYSIS' named entity 'NSP1' named entity 'NSP1' named entity 'POLYPROTEIN' named entity 'VACCINE DEVELOPMENT' named entity 'INFECTION' named entity 'IMPACT' named entity 'SIGNALING' named entity 'CELLS' named entity 'STAT1' covid:arg/0a62c80536aac29f30a65d03070fe79f9e8705c5 named entity 'inhibited' named entity 'pathogenesis' named entity 'existence'

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