About: Demyelination in canine distemper encephalomyelitis: An ultrastructural analysis

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About: Demyelination in canine distemper encephalomyelitis: An ultrastructural analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Demyelination in canine distemper encephalomyelitis: An ultrastructural analysis
Creator	Appel, Max Summers, Brian
source	PMC
abstract	A morphological study of selected white matter lesions was carried out in three dogs with canine distemper encephalomyelitis. Two dogs had experimental infections while the third was a spontaneous case. Two stages were identified in the process of demyelination. The earliest evidence of myelin injury was a ballooning change in myelin sheaths involving single or multiple axons. This was followed by a progressive stripping of compact sheaths by the cytoplasmic fingers of phagocytic cells which infiltrated and removed myelin lamellae. Some axonal necrosis also accompanied these changes. Where demyelination occurred, canine distemper viral nucleocapsids were found in astrocytes, macrophages, ependymal cells and infiltrating lymphocytes. In contrast, oligodendrocytes were conspicuous by their apparent lack of infection. Thus it seems that myelin loss cannot be ascribed to oligodendrocyte infection. Perturbed astrocyte function following canine distemper viral infection may cause oedema of myelin sheaths, leading to ballooning and primary demyelination. Cells which phagocytosed myelin were mainly identified as microglial cells with lesser involvement by astrocytes. Rarely, oligodendrocytes also acted as macrophages. Myelin debris was engulfed in bulk or as small droplets into coated pits. Remyelination was present in established plaques although not in great abundance, perhaps due to the diminished oligodendrocyte numbers and a relative increase in immature forms of these cells. These observations are compared to similar changes observed in other demyelinating diseases of animals and man.
has issue date	1987-01-01(xsd:dateTime)
bibo:doi	10.1007/bf01611991
bibo:pmid	3450794
has license	no-cc
sha1sum (hex)	09ed223aabf995f91f8e164b78a4491c28d2b19f
schema:url	https://doi.org/10.1007/bf01611991
resource representing a document's title	Demyelination in canine distemper encephalomyelitis: An ultrastructural analysis
has PubMed Central identifier	PMC7089302
has PubMed identifier	3450794
schema:publication	J Neurocytol
resource representing a document's body	covid:09ed223aabf995f91f8e164b78a4491c28d2b19f#body_text
is schema:about of	named entity 'stripping' named entity 'debris' named entity 'axons' named entity 'infection' named entity 'canine distemper' »more»

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