About: Translation of viral mRNAs that do not require eIF4E is blocked by the inhibitor 4EGI-1

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About: Translation of viral mRNAs that do not require eIF4E is blocked by the inhibitor 4EGI-1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Translation of viral mRNAs that do not require eIF4E is blocked by the inhibitor 4EGI-1
Creator	Carrasco, Luis García-Moreno, Manuel Redondo, Natalia Sanz, Miguel
Source	Elsevier; Medline; PMC
abstract	High throughput screening has rendered new inhibitors of eukaryotic protein synthesis. One such molecule, 4EGI-1 has been reported to selectively block the initiation factor eIF4E. We have investigated the action of this inhibitor on translation directed by several viral mRNAs which, in principle, do not utilize eIF4E. We found that 4EGI-1 inhibits translation directed by poliovirus IRES, in rabbit reticulocyte lysates, to a similar extent as capped mRNA. Moreover, 4EGI-1 inhibits translation driven by poliovirus IRES, both in vitro and in cultured cells, despite cleavage of eIF4G by picornavirus proteases. Finally, translation of vesicular stomatitis virus mRNAs and Sindbis virus subgenomic mRNA is blocked by 4EGI-1 in infected cells to a similar extent as cellular mRNAs. These findings cast doubt on the selective action of this inhibitor, and suggest that this molecule may affect other steps in protein synthesis unrelated to cap recognition by eIF4E.
has issue date	2013-07-17(xsd:dateTime)
bibo:doi	10.1016/j.virol.2013.06.008
bibo:pmid	23870416
has license	no-cc
sha1sum (hex)	09cf397b5f64ecb81f5a21b0683465fa9d5a7e2a
schema:url	https://doi.org/10.1016/j.virol.2013.06.008
resource representing a document's title	Translation of viral mRNAs that do not require eIF4E is blocked by the inhibitor 4EGI-1
has PubMed Central identifier	PMC7111898
has PubMed identifier	23870416
schema:publication	Virology
resource representing a document's body	covid:09cf397b5f64ecb81f5a21b0683465fa9d5a7e2a#body_text
is schema:about of	named entity 'block' named entity 'eIF4E' named entity 'directed' named entity 'FINDINGS' named entity 'CAST' named entity 'IRES' named entity 'IN VITRO' named entity 'UNRELATED' named entity 'CAP' named entity 'VESICULAR STOMATITIS VIRUS' named entity 'DRIVEN' named entity 'INHIBITOR' named entity 'BLOCKED' named entity 'mRNA' named entity 'eIF4G' named entity 'cleavage' named entity 'protein synthesis' named entity 'mRNAs' named entity 'IRES' named entity 'High throughput screening' named entity 'action' named entity 'poliovirus' named entity 'Sindbis' named entity 'High throughput screening' named entity 'picornavirus' named entity 'eIF4E' named entity 'mRNA' named entity 'eIF4G' named entity 'poliovirus' named entity 'reticulocyte' named entity 'mRNAs' named entity 'subgenomic mRNA' named entity 'cellular' named entity 'Dynabeads' named entity 'IRES' named entity 'protein synthesis' named entity 'BHK-21 cells' named entity 'eIF4G' named entity 'Plasmid' named entity 'eIF4E' named entity 'biological effects' named entity 'Western blot' named entity 'IRES' named entity 'BHK-21 cells' named entity 'eIF4G' named entity 'xenografts' named entity 'eIF4GI' named entity 'Perkin Elmer' named entity 'PBS' named entity 'eIF4E' named entity '1:500' named entity 'GTP' named entity 'antibody' named entity 'BHK-21 cells' named entity 'VSV' named entity 'serum' named entity '4EGI-1' named entity '4EGI-1' named entity 'inhibitory activity' named entity 'EMCV' named entity 'eIF4G' named entity 'N-terminal' named entity 'EMCV' named entity 'IRES' named entity 'protein' named entity 'luciferase' named entity 'eIF4GI' named entity '4EGI-1' named entity 'Protein synthesis' named entity 'hpi' named entity '4EGI-1' named entity 'co-precipitation' named entity 'eIF4G' named entity 'EMCV' named entity 'foot-and-mouth disease virus' named entity '4EGI-1' named entity 'antibody' named entity '4EGI-1'

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