About: Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media

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About: Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media
Creator	Ruuskanen, Olli Waris, Matti Ruohola, Aino Huovinen, Pentti Jalava, Jari Lahti, Elina Lindholm, Laura Pettigrew, Melinda Laine, Miia Vainionp, Raija
Source	Elsevier; Medline; PMC
abstract	SUMMARY OBJECTIVES: To understand relationships between microbes in pathogenesis of acute otitis media during respiratory tract infections, we compared nasopharyngeal bacteria and respiratory viruses in symptomatic children with and without AOM. METHODS: We enrolled children (6–35 months) with acute symptoms suggestive of AOM and analyzed their nasopharyngeal samples for bacteria by culture and for 15 respiratory viruses by PCR. Non-AOM group had no abnormal otoscopic signs or only middle ear effusion, while AOM group showed middle ear effusion and acute inflammatory signs in pneumatic otoscopy along with acute symptoms. RESULTS: Of 505 children, the non-AOM group included 187 and the AOM group 318. One or more bacterial AOM pathogen (Streptococcus pneumoniae, Haemophilus influenzae, or Moraxella catarrhalis) was detected in 78% and 96% of the non-AOM and AOM group, respectively (P < .001). Colonization with S. pneumoniae and H. influenzae, each alone, increased risk of AOM (odds ratio (OR) 2.92; 95% confidence interval (CI), .91–9.38, and 5.13; 1.36–19.50, respectively) and co-colonization with M. catarrhalis further increased risk (OR 4.36; 1.46–12.97, and 9.00; 2.05–39.49, respectively). Respiratory viruses were detected in 90% and 87% of the non-AOM and AOM group, respectively. RSV was significantly associated with risk of AOM without colonization by bacterial AOM pathogens (OR 6.50; 1.21–34.85). CONCLUSIONS: Co-colonization by M. catarrhalis seems to increase risk of AOM and RSV may contribute to AOM pathogenesis even without nasopharyngeal bacterial colonization.
has issue date	2013-03-01(xsd:dateTime)
bibo:doi	10.1016/j.jinf.2012.12.002
bibo:pmid	23266462
has license	green-oa
sha1sum (hex)	09a6daa803fb5aba5cc6ae2cef54c24c5a661d6f
schema:url	https://doi.org/10.1016/j.jinf.2012.12.002
resource representing a document's title	Bacterial and viral interactions within the nasopharynx contribute to the risk of acute otitis media
has PubMed Central identifier	PMC3571106
has PubMed identifier	23266462
schema:publication	Journal of Infection
resource representing a document's body	covid:09a6daa803fb5aba5cc6ae2cef54c24c5a661d6f#body_text
is schema:about of	named entity 'RISK OF' named entity 'RSV' named entity 'confidence interval' named entity 'Objectives' named entity 'symptoms' named entity 'nasopharynx' named entity 'RATIO' named entity 'BACTERIA ' named entity 'NON-' named entity 'SAMPLES' named entity 'UNDERSTAND' named entity 'CONCLUSIONS' named entity 'ACUTE OTITIS MEDIA' named entity 'CHILDREN' named entity 'S. PNEUMONIAE' named entity 'AOM' named entity 'NO ABNORMAL' named entity 'BACTERIAL' named entity 'MONTHS' named entity 'GROUP' named entity 'SIGNS' named entity 'VIRAL' named entity 'RELATIONSHIPS' named entity 'ASSOCIATED WITH' covid:arg/09a6daa803fb5aba5cc6ae2cef54c24c5a661d6f named entity '90%' named entity 'PNEUMONIAE' named entity 'MORAXELLA CATARRHALIS' named entity 'BACTERIAL COLONIZATION' named entity 'DETECTED' named entity 'ENROLLED' named entity 'COLONIZATION' named entity 'CONTRIBUTE ' named entity '28P' named entity 'NASOPHARYNX' named entity 'TO INCREASE' named entity 'ACUTE' named entity 'THEIR' named entity 'SYMPTOMATIC' named entity 'RISK OF' named entity 'ACUTE OTITIS MEDIA' named entity 'BACTERIAL' named entity 'COMPARED' named entity 'METHODS' named entity '187' named entity 'OBJECTIVES' named entity 'PATHOGENESIS' named entity 'CONTRIBUTE ' named entity 'RESPIRATORY VIRUSES' named entity 'INCREASED RISK' named entity 'PCR' named entity 'SYMPTOMS' named entity 'RESULTS' named entity 'CULTURE' named entity 'JOURNAL ' named entity 'PNEUMATIC OTOSCOPY' named entity 'INFLAMMATORY' named entity 'SUGGESTIVE OF' named entity 'ANALYZED' named entity 'INTERACTIONS' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'HAEMOPHILUS INFLUENZAE' named entity 'RSV' named entity 'CONFIDENCE INTERVAL' named entity 'NASOPHARYNGEAL' named entity 'PATHOGEN' named entity '50%' named entity 'MIDDLE EAR EFFUSION' named entity 'INFECTION' named entity 'MICROBES' named entity 'INCLUDED' named entity 'PATHOGENS'

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