About: Speculation on whether a vaccine against cryptosporidiosis is a reality or fantasy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Speculation on whether a vaccine against cryptosporidiosis is a reality or fantasy
Creator	Bonnin, Alain Petry, Franz Sagodira, Serge Spano, Furio De Graaf, Dirk
Source	Elsevier; Medline; PMC
abstract	Abstract In this paper the authors question whether the development of a vaccine against cryptosporidiosis could be taken into consideration. The necessity and feasibility of such a vaccine for human and veterinary application is discussed. Developmental stages within the life cycle of the parasite that might act as possible targets for vaccine development are summarised, as well as the target antigens offered by molecular biology and immunology studies. Vaccination trials against cryptosporidiosis carried out so far, including the active and passive immunisation approach, are also overviewed. It seems that with respect to a Cryptosporidium vaccine two target groups can be considered: children of the developing world and neonatal ruminants. Antigens representing possible candidates for a subunit vaccine were identified based on their function, location and/or the immune response they evoke. While the active vaccination of newborn calves, lambs and goat kids has to face a number of important limitations, the passive immunisation approach, where dams were immunised to protect their progeny by colostral transfer, was proven to be a valuable alternative. Finally, a number of points of action for the near future are put forward.
has issue date	1999-08-31(xsd:dateTime)
bibo:doi	10.1016/s0020-7519(99)00082-x
bibo:pmid	10576579
has license	els-covid
sha1sum (hex)	09a248034a8e29a2341c707ef66771cda8bd7b1b
schema:url	https://doi.org/10.1016/s0020-7519%2899%2900082-x
resource representing a document's title	Speculation on whether a vaccine against cryptosporidiosis is a reality or fantasy
has PubMed Central identifier	PMC7130201
has PubMed identifier	10576579
schema:publication	International Journal for Parasitology
resource representing a document's body	covid:09a248034a8e29a2341c707ef66771cda8bd7b1b#body_text
is schema:about of	named entity 'life cycle' named entity 'passive immunisation' named entity 'cryptosporidiosis' named entity 'The' named entity 'cryptosporidiosis' named entity 'VACCINE' covid:arg/09a248034a8e29a2341c707ef66771cda8bd7b1b named entity 'DEVELOPMENT' named entity 'ACTIVE' named entity 'LIMITATIONS' named entity 'REALITY' named entity 'GOAT KIDS' named entity 'NEWBORN' named entity 'CRYPTOSPORIDIUM' named entity 'PARASITE' named entity 'FEASIBILITY' named entity 'HUMAN' named entity 'SUBUNIT VACCINE' named entity 'LAMBS' named entity 'RUMINANTS' named entity 'FUNCTION' named entity 'TAKEN' named entity 'VACCINATION' named entity 'ALTERNATIVE' named entity 'IMMUNOLOGY STUDIES' named entity 'VACCINE DEVELOPMENT' named entity 'WORLD' named entity 'PAPER' named entity 'APPLICATION' named entity 'APPROACH' named entity 'DEVELOPING' named entity 'FUTURE' named entity 'BASED' named entity 'PROGENY' named entity 'THEIR' named entity 'VETERINARY' named entity 'GROUPS' named entity 'CONSIDERED' named entity 'PROVEN' named entity 'CARRIED' named entity 'MOLECULAR BIOLOGY' named entity 'ACTION' named entity 'POSSIBLE' named entity 'FORWARD' named entity 'INCLUDING' named entity 'IS A' named entity 'CRYPTOSPORIDIOSIS' named entity 'NECESSITY' named entity 'LOCATION' named entity 'DEVELOPMENTAL STAGES' named entity 'WHERE' named entity 'CHILDREN' named entity 'AUTHORS' named entity 'NUMBER OF' named entity 'ANTIGENS' named entity 'FANTASY' named entity 'SPECULATION' named entity 'CALVES' named entity 'NUMBER OF POINTS' named entity 'TRANSFER' named entity 'ACT' named entity 'DAMS' named entity 'CRYPTOSPORIDIOSIS' named entity 'RESPECT' named entity 'PASSIVE IMMUNISATION' named entity 'VACCINE' named entity 'TARGET' named entity 'CONSIDERATION' named entity 'NEAR' named entity 'COULD BE' named entity 'NEONATAL' named entity 'ACTIVE VACCINATION' named entity 'TARGETS' named entity 'FACE' named entity 'IMPORTANT' named entity 'LIFE CYCLE' named entity 'FAR'

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