About: In vitro evaluation of antioxidant activities of aqueous extracts from natural and cultured mycelia of Cordyceps sinensis

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	In vitro evaluation of antioxidant activities of aqueous extracts from natural and cultured mycelia of Cordyceps sinensis
Creator	Dong, C.-H Yao, Y.-J
source	Elsevier; Medline; PMC
abstract	Abstract Cordyceps sinensis, one of the best known traditional Chinese medicines and health foods, has been highly valued for the treatment of a wide range of diseases and reported to have antioxidant properties. In the present study, the antioxidant activities of hot-water extracts from natural and cultured mycelia of C. sinensis were investigated and evaluated using six in vitro assays, including inhibition of linoleic acid peroxidation; scavenging abilities on DPPH, hydroxyl and superoxide anion radicals; the reducing power and the chelating ability on ferrous ions. Among these assays, the extracts showed the best effect on the inhibition of linoleic peroxidation with the lowest IC50 values and with an inhibition rate over 90% at concentration of 0.8–1.6mg/ml, more stable than that of α-tocopherol, a recognised natural antioxidant. The scavenging activities on superoxide anion and hydroxyl radicals of the two extracts were slightly lower than that of butylated hydroxytoluene. DPPH scavenging activities of both extracts reached over 80% inhibition at 4–8mg/ml. Both extracts showed moderate reducing power and ferrous ion chelating activity. The IC50 value of the extract from cultured mycelia in all the tests, except for linoleic acid peroxidation, was significantly lower than that of natural mycelia. There was no evident correlation between the antioxidant activity and the content of protein, polysaccharides and mannitol of extracts from C. sinensis; the antioxidant activity may be due to a combined effect of these or some other compounds. These results suggested that both the extracts from cultured and natural mycelia have direct and potent antioxidant activities and that the cultured mycelia of the fungus could be used for the antioxidant activity to reduce the human demands on the natural resources of the fungus, an endangered species.
has issue date	2008-05-31(xsd:dateTime)
bibo:doi	10.1016/j.lwt.2007.05.002
bibo:pmid	32287390
has license	els-covid
sha1sum (hex)	097529f4d953e2729951ac0f2ba6a001c6534146
schema:url	https://doi.org/10.1016/j.lwt.2007.05.002
resource representing a document's title	In vitro evaluation of antioxidant activities of aqueous extracts from natural and cultured mycelia of Cordyceps sinensis
has PubMed Central identifier	PMC7126362
has PubMed identifier	32287390
schema:publication	LWT - Food Science and Technology
resource representing a document's body	covid:097529f4d953e2729951ac0f2ba6a001c6534146#body_text
is schema:about of	named entity 'IN VITRO' named entity 'natural' named entity 'assays' named entity 'peroxidation' named entity 'scavenging' named entity 'activities' named entity 'superoxide' named entity 'ability' named entity 'cultured' named entity 'chelating' named entity 'activities' named entity 'antioxidant' named entity 'radicals' named entity 'inhibition' named entity 'extracts' named entity 'EVALUATION' named entity 'HYDROXYL ' named entity 'REPORTED' named entity 'TREATMENT' named entity 'FERROUS' named entity 'MODERATE' named entity 'A-TOCOPHEROL' named entity 'SLIGHTLY' named entity 'PROPERTIES' named entity 'SUPEROXIDE ANION' named entity 'CHELATING' named entity 'RATE' named entity 'BEST' named entity 'IONS' named entity 'HAVE' named entity 'USING' named entity 'WIDE' named entity 'FUNGUS' named entity '1.6' named entity 'ANTIOXIDANT' named entity 'TRADITIONAL' named entity 'CORRELATION' named entity 'ACTIVITIES' named entity 'THESE' named entity 'PEROXIDATION' named entity 'COMBINED EFFECT' named entity 'KNOWN' named entity 'LINOLEIC ACID' named entity 'HOT' named entity 'LOWER' named entity 'INHIBITION' named entity '0.8' named entity 'NATURAL RESOURCES' named entity 'STUDY' named entity 'TESTS' named entity 'HUMAN' named entity 'RESULTS' named entity 'VALUE' named entity 'NATURAL ANTIOXIDANT' named entity 'DUE TO' named entity 'CONCENTRATION OF' named entity 'ONE OF' named entity 'NATURAL' named entity 'IC50' named entity 'PROTEIN' named entity 'EXTRACT' named entity 'LOWEST' named entity 'DIRECT' named entity 'ABILITY' named entity 'CORDYCEPS SINENSIS' named entity 'INVESTIGATED' named entity 'BUTYLATED HYDROXYTOLUENE' named entity 'USED' named entity 'DEMANDS' named entity 'VALUES' named entity 'EXTRACTS' named entity 'CORDYCEPS SINENSIS' named entity 'CULTURED' named entity 'ACTIVITIES' named entity 'RADICALS' named entity '80%' named entity 'EVALUATED' named entity 'MAY BE' named entity 'REDUCING' named entity 'MANNITOL'

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