About: Determining a sampling regime for PCR detection of respiratory tract viral infection at coronial post-mortem examinations

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About: Determining a sampling regime for PCR detection of respiratory tract viral infection at coronial post-mortem examinations Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Determining a sampling regime for PCR detection of respiratory tract viral infection at coronial post-mortem examinations
Creator	Higgins, Geoff Gilsenan-Reed, Caitlin Langlois, Neil
Source	Medline; PMC
abstract	Death due to respiratory infection is commonly encountered at autopsy. With only one opportunity to obtain samples for identification of a causative agent, it is important to ensure that sampling regimes are optimized to provide the greatest detection, without the expense and redundancy that can arise from over-sampling. This study was performed retrospectively using data from Coronial autopsies over the period 2012–2019 from which swabs from the nasopharyngeal region, trachea and lung parenchyma, in addition to samples of lung tissue, had been submitted for multiplex PCR detection of respiratory pathogens. From 97 cases with all four samples, there were 24 with at least one positive result for viral infection. Some cases had multiple positive results and a total of 27 respiratory tract viruses were identified, of which rhinovirus, influenza A virus and respiratory syncytial virus were the most common. Seventeen of the 27 viral infections (63%) were identified in all four samples. However, in nearly all cases (96%) the nasopharyngeal swab detected the infective agent when the multiplex PCR panel had detected infection in any of the four sample types. A nasopharyngeal swab is considered to be an optimal sample for detection of respiratory tract viral infection. As the samples analyzed were acquired before the appearance of the COVID-19 virus, the applicability of this finding for COVID-19 screening is not established.
has issue date	2020-06-23(xsd:dateTime)
bibo:doi	10.1007/s12024-020-00273-w
bibo:pmid	32578131
has license	cc-by
sha1sum (hex)	094730f7b4ccfb240668fcd2bc938811e98eb3f3
schema:url	https://doi.org/10.1007/s12024-020-00273-w
resource representing a document's title	Determining a sampling regime for PCR detection of respiratory tract viral infection at coronial post-mortem examinations
has PubMed Central identifier	PMC7308444
has PubMed identifier	32578131
schema:publication	Forensic Sci Med Pathol
resource representing a document's body	covid:094730f7b4ccfb240668fcd2bc938811e98eb3f3#body_text
is schema:about of	named entity 'autopsies' named entity 'multiplex PCR' named entity 'commonly' named entity 'respiratory' named entity 'multiplex PCR' named entity 'PCR' named entity 'DEATH' named entity 'RESPIRATORY INFECTION' named entity 'AUTOPSY' named entity 'IDENTIFIED' named entity '2896' named entity 'SAMPLES' named entity 'CASES' named entity 'ANALYZED' named entity 'SAMPLE' named entity 'OBTAIN' named entity 'OPTIMAL' covid:arg/094730f7b4ccfb240668fcd2bc938811e98eb3f3 named entity 'viruses' named entity 'optimal' named entity 'encountered' named entity 'respiratory infection' named entity 'provide' named entity 'positive' named entity 'result' named entity 'samples' named entity 'rhinovirus' named entity 'virus' named entity 'Some' named entity 'influenza A virus' named entity 'viral infection' named entity 'infective agent' named entity 'COVID-19 virus' named entity 'respiratory syncytial virus' named entity 'autopsy' named entity 'viruses' named entity 'nasopharyngeal swab' named entity 'viral infection' named entity 'pathogens' named entity 'respiratory infection' named entity 'viral infection' named entity 'lung tissue' named entity 'virus' named entity 'viruses' named entity 'viral infection' named entity 'cystic fibrosis' named entity 'nasopharyngeal swabs' named entity 'respiratory tract' named entity 'post-mortem examination' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'post-mortem' named entity 'nucleic acid' named entity 'autopsy' named entity 'Forensic Science' named entity 'viruses' named entity 'influenza' named entity 'lung' named entity 'referred to the Coroner' named entity 'lung tissue' named entity 'respiratory tract' named entity 'lung tissue' named entity 'respiratory tract infection' named entity 'RSV' named entity 'Nasopharyngeal swabs' named entity 'statistically significant' named entity 'viruses' named entity 'microbiological' named entity 'Lung tissue' named entity 'Human metapneumovirus' named entity 'viruses' named entity 'autopsy' named entity 'virus' named entity 'Royal College of Pathologists' named entity 'viral infection' named entity 'autopsied' named entity 'pathology' named entity 'infectious agent' named entity 'Creative Commons licence' named entity 'lung'

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