About: Interferon-α Improves Phosphoantigen-Induced Vγ9Vδ2 T-Cells Interferon-γ Production during Chronic HCV Infection

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon-α Improves Phosphoantigen-Induced Vγ9Vδ2 T-Cells Interferon-γ Production during Chronic HCV Infection
Creator	Agrati, Chiara Bordoni, Veronica Lalle, Eleonora Gioia, Cristiana Martini, Federico Cimini, Eleonora Sacchi, Alessandra Berno, Giulia Sicard, Helene Vlassi, Chrysoula Capobianchi, Maria Comandini, Ubaldo Cé Cile Bonnafous, D'offizi, Gianpiero
Source	Medline; PMC
abstract	In chronic HCV infection, treatment failure and defective host immune response highly demand improved therapy strategies. Vγ9Vδ2 T-cells may inhibit HCV replication in vitro through IFN-γ release after Phosphoantigen (PhAg) stimulation. The aim of our work was to analyze Vγ9Vδ2 T-cell functionality during chronic HCV infection, studying the role of IFN-α on their function capability. IFN-γ production by Vγ9Vδ2 T-cells was analyzed in vitro in 24 HCV-infected patients and 35 healthy donors (HD) after PhAg stimulation with or without IFN-α. The effect of in vivo PhAg/IFN-α administration on plasma IFN-γ levels was analyzed in M. fascicularis monkeys. A quantitative analysis of IFN-γ mRNA level and stability in Vγ9Vδ2 T-cells was also evaluated. During chronic HCV infection, Vγ9Vδ2 T-cells showed an effector/activated phenotype and were significantly impaired in IFN-γ production. Interestingly, IFN-α was able to improve their IFN-γ response to PhAg both in vitro in HD and HCV-infected patients, and in vivo in Macaca fascicularis primates. Finally, IFN-α increased IFN-γ-mRNA transcription and stability in PhAg-activated Vγ9Vδ2 T-cells. Altogether our results show a functional impairment of Vγ9Vδ2 T-cells during chronic HCV infection that can be partially restored by using IFN-α. A study aimed to evaluate the antiviral impact of PhAg/IFN-α combination may provide new insight in designing possible combined strategies to improve HCV infection treatment outcome.
has issue date	2012-05-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0037014
bibo:pmid	22629350
has license	cc-by
sha1sum (hex)	0943374130f5f8474d6d480d4d038615a0e36de3
schema:url	https://doi.org/10.1371/journal.pone.0037014
resource representing a document's title	Interferon-α Improves Phosphoantigen-Induced Vγ9Vδ2 T-Cells Interferon-γ Production during Chronic HCV Infection
has PubMed Central identifier	PMC3358305
has PubMed identifier	22629350
schema:publication	PLoS One
resource representing a document's body	covid:0943374130f5f8474d6d480d4d038615a0e36de3#body_text
is schema:about of	named entity 'HEALTHY' named entity 'IMPROVED' named entity 'RESULTS' named entity 'PHENOTYPE' named entity 'RESPONSE TO' named entity 'MACACA FASCICULARIS' named entity 'STABILITY' named entity 'T-CELLS' named entity 'CAPABILITY' named entity 'IMPACT' named entity 'DEFECTIVE' named entity 'PATIENTS' named entity 'STIMULATION' named entity 'POSSIBLE' named entity 'MRNA' named entity 'INCREASED' named entity 'PRODUCTION' named entity 'TREATMENT OUTCOME' named entity 'CELL FUNCTIONALITY' named entity 'STUDY' named entity 'DEMAND' named entity 'CHRONIC' named entity 'HOST IMMUNE RESPONSE' named entity 'REPLICATION' named entity 'THEIR' named entity 'HCV' named entity 'T-CELL' named entity 'ADMINISTRATION' named entity 'COMBINED' named entity 'EFFECT' named entity 'STRATEGIES' named entity 'IFN' named entity 'NEW' named entity 'TREATMENT FAILURE' named entity 'WORK' named entity 'PRODUCTION' named entity 'EFFECTOR' named entity 'MONKEYS' named entity 'FUNCTIONAL IMPAIRMENT' named entity 'ROLE' named entity 'HCV INFECTION' named entity 'IFN-A' named entity 'IMPAIRED' named entity 'LEVELS' named entity 'LEVEL' named entity 'ACTIVATED' named entity 'INTERFERON' named entity 'CHRONIC' named entity 'PHOSPHOANTIGEN' named entity 'HCV INFECTION' named entity 'INDUCED' named entity 'IMPROVES' named entity 'T-CELLS' named entity 'HIGHLY' named entity 'DONORS' named entity 'RELEASE' named entity 'PHOSPHOANTIGEN' named entity 'INSIGHT' named entity 'PLASMA' named entity 'ANTIVIRAL' named entity 'MRNA TRANSCRIPTION' named entity 'USING' named entity 'INFECTED' named entity 'EVALUATE' named entity 'AIM' named entity 'PROVIDE' named entity 'OUR' named entity 'IN VITRO'

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