About: The Cumulative Rate of SARS-CoV-2 Infection in Chinese Hemodialysis Patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Cumulative Rate of SARS-CoV-2 Infection in Chinese Hemodialysis Patients
Creator	Xu, Xin Liang, Min Huang, Ailong Zha, Yan Sun, Jian Li, Dongfeng Shao, Yong Li, M Liang, Y Ff, Hou Gao, Shikui Hou, Fan Kong, Sun Kong, Yaozhong Ma, Tean Nie, Sheng Peng, Gangyi Peng, Jiaqing Ren, Chanjun
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: There is a paucity of information regarding SARS-CoV-2 infection in patients undergoing maintenance hemodialysis. We aimed to estimate the cumulative attack rate of SARS-CoV-2 in hemodialysis patients in China using a serological test. METHOD: We enrolled all hemodialysis patients from 8 hemodialysis facilities in Honghu and Jingzhou of Huibei province and Guangzhou and Foshan of Guangdong province in China. We screened these patients for SARS-CoV-2 infection by both a RT–PCR test for viral RNA and a serological test for IgG and IgM antibodies. Data on demographics and clinical characteristics were collected via case report forms. We also enrolled the healthcare workers (HCWs) from the participating hospitals and compared the seropositive rate between hemodialysis patients and HCWs in the same region. RESULT: Among 1,542 hemodialysis patients, 5 (0.32%) and 51 (3.3%) were tested positive by the RT-PCR test and the serological test, respectively. The seropositive rate in Hubei (3.6%) was higher than that in Guangdong (2.8%), though the difference was not statistically significant (p=0.5). Most of the seropositive patients were asymptomatic. Older than 65 years, having manifestation of lung infection in imaging examines, and lower level of serum albumin were independent risk factors for SARS-CoV-2 infection. In comparison, the seropositive rate in 3,205 HCWs was 1.2% which was significantly lower than that observed in the hemodialysis patients (p<0.001). CONCLUSION: The cumulative rate of SARS-CoV-2 infection in hemodialysis patients in China was high at 3.3%. Serological test detected 10 times more cases of SARS-CoV-2 infection than the RT-PCR test and should be the preferred tool for estimating the prevalence of COVID-19.
has issue date	2020-07-18(xsd:dateTime)
bibo:doi	10.1016/j.ekir.2020.07.010
bibo:pmid	32838083
has license	no-cc
sha1sum (hex)	092d213981ee20165fc4f4175a1f6ed70840f490
schema:url	https://doi.org/10.1016/j.ekir.2020.07.010
resource representing a document's title	The Cumulative Rate of SARS-CoV-2 Infection in Chinese Hemodialysis Patients
has PubMed Central identifier	PMC7368651
has PubMed identifier	32838083
schema:publication	Kidney Int Rep
resource representing a document's body	covid:092d213981ee20165fc4f4175a1f6ed70840f490#body_text
is schema:about of	named entity 'IgM' named entity 'patients' named entity 'SARS-CoV-2' covid:arg/092d213981ee20165fc4f4175a1f6ed70840f490 named entity 'attack rate' named entity 'China' named entity 'patients' named entity 'hemodialysis' named entity 'hemodialysis' named entity 'IgG' named entity 'Abstract' named entity 'word count' named entity 'Infection' named entity 'IgM antibodies' named entity 'hemodialysis' named entity 'hemodialysis' named entity 'Honghu' named entity 'Infection' named entity 'seropositive' named entity 'seropositive' named entity 'COVID' named entity 'Hubei' named entity 'Chemiluminescence' named entity 'chest CT' named entity 'epidemic' named entity 'Hubei' named entity 'severe epidemic' named entity 'hemodialysis' named entity 'lung infection' named entity 'ground-glass opacity' named entity 'serological test' named entity 'COVID' named entity 'healthcare workers' named entity 'IgG' named entity 'hemodialysis' named entity 'cross-sectional design' named entity 'Kaplan-Meier method' named entity 'hemodialysis' named entity 'seropositive' named entity 'COVID' named entity 'risk factors' named entity 'Medical Ethics' named entity 'lung infection' named entity 'SARS-CoV-2' named entity 'antibodies' named entity 'infection' named entity 'RNA' named entity 'dialysis' named entity 'IgM' named entity 'disease prevalence' named entity 'nursing home' named entity 'seropositive' named entity 'vaccine' named entity 'end-stage kidney disease' named entity 'subclinical' named entity 'infection' named entity 'laboratory tests' named entity 'hemodialysis' named entity 'Chi-square test' named entity 'dyspnea' named entity 'COVID' named entity 'infection' named entity 'lung infection'

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