About: Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters

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About: Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters
Creator	Baltina, L Kondratenko, R Plyasunova, O Chistoedova, E
Source	Medline; PMC
abstract	New conjugates of 18β- and 18α-glycyrrhizic acids (GAs) each containing two di- or α-methyl esters of L-aspartic acid in the carbohydrate part of the glycosides were synthesized by the activated ester method using the N-hydroxysuccinimide (HOSu) and N,N'-dicyclohexylcarbodiimide. It was found that the conjugate of 18β-GA with Asp(OMe)(OMe) (4) at a concentration of 250 μg/mL inhibited effectively RT of HIV-1 and the accumulation of virus antigen p24 in MT-4 cell culture (95–97 %) and protected cells from the cytopathogenic action of the virus.
has issue date	2012-05-16(xsd:dateTime)
bibo:doi	10.1007/s10600-012-0217-1
bibo:pmid	32214422
has license	no-cc
sha1sum (hex)	08ecf83a52557998484a4af1d660d62c77482568
schema:url	https://doi.org/10.1007/s10600-012-0217-1
resource representing a document's title	Synthesis and anti-HIV-1 activity of new conjugates of 18β- and 18α-glycyrrhizic acids with aspartic acid esters
has PubMed Central identifier	PMC7088273
has PubMed identifier	32214422
schema:publication	Chem Nat Compd
resource representing a document's body	covid:08ecf83a52557998484a4af1d660d62c77482568#body_text
is schema:about of	named entity 'p24' named entity 'antigen' named entity 'HIV-1' named entity 'CONTAINING' named entity 'VIRUS ANTIGEN' named entity 'L-ASPARTIC ACID' named entity '18E' named entity 'CONJUGATE' named entity 'accumulation' named entity 'effectively' named entity 'virus' named entity 'virus' named entity 'inhibited' named entity 'ACID' named entity 'cell culture' named entity 'HIV-1' named entity 'L-aspartic acid' named entity 'virus replication cycle' named entity 'Asp' named entity 'MgSO' named entity 'diazomethane' named entity '5.5' named entity 'MeOH' named entity 'dipeptides' named entity 'aglycon' named entity 'ester' named entity 'HCl' named entity 'aspartate' named entity 'NEM' named entity 'methoxy' named entity 'licorice' named entity 'L-aspartic acid' named entity 'antiviral activity' named entity 'OSu' named entity 'G. uralensis' named entity 'stereoisomer' named entity '5.5' named entity 'calcined' named entity 'aspartic acid' named entity 'T-lymphocyte' named entity 'antiviral' named entity 'filtrate' named entity 'THF' named entity 'IR spectrum' named entity 'tert-Butyl' named entity 'bimolecular nucleophilic substitution' named entity 'silica gel' named entity 'mechanism of action' named entity 'COOH' named entity 'dioxane' named entity 'ester' named entity 'structure-activity relationship' named entity 'viral DNA' named entity 'OMe' named entity 'AZT' named entity 'ppm' named entity 'virus' named entity 'COOH' named entity 'BaO' named entity 'glycoside' named entity 'Novosibirsk Oblast' named entity 'staining' named entity 'sterically hindered' named entity 'esters' named entity 'NMR spectra' named entity 'protons' named entity 'chemical shift' named entity 'virus' named entity 'activated ester' named entity 'aglycon' named entity 'carbohydrate' named entity 'UV spectrum' named entity 'AZT' named entity 'amino acids' named entity 'NMR spectra' named entity 'anti-HIV' named entity 'p24' named entity 'MeOH'

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