About: Animal models for SARS and MERS coronaviruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Animal models for SARS and MERS coronaviruses
Creator	Subbarao, Kanta Gretebeck, Lisa
Source	Elsevier; Medline; PMC
abstract	The emergence of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Respiratory Syndrome coronavirus (MERS-CoV), two strains of animal coronaviruses that crossed the species barrier to infect and cause severe respiratory infections in humans within the last 12 years, have taught us that coronaviruses represent a global threat that does not recognize international borders. We can expect to see other novel coronaviruses emerge in the future. An ideal animal model should reflect the clinical signs, viral replication and pathology seen in humans. In this review, we present factors to consider in establishing an animal model for the study of novel coronaviruses and compare the different animal models that have been employed to study SARS-CoV and MERS-CoV.
has issue date	2015-08-01(xsd:dateTime)
bibo:doi	10.1016/j.coviro.2015.06.009
bibo:pmid	26184451
has license	bronze-oa
sha1sum (hex)	08cd7c215584f4c46d198988d3b3feb276067552
schema:url	https://doi.org/10.1016/j.coviro.2015.06.009
resource representing a document's title	Animal models for SARS and MERS coronaviruses
has PubMed Central identifier	PMC4550498
has PubMed identifier	26184451
schema:publication	Current Opinion in Virology
resource representing a document's body	covid:08cd7c215584f4c46d198988d3b3feb276067552#body_text
is schema:about of	named entity 'SARS' named entity 'infect' named entity 'expect' named entity 'future' named entity 'pathology' named entity 'EMPLOYED' named entity 'BARRIER' named entity 'ANIMAL' named entity 'SARS-COV' named entity 'COMPARE' named entity 'YEARS' named entity 'RECOGNIZE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS' named entity 'CAUSE' named entity 'STUDY' named entity 'THREAT' named entity 'EMERGENCE' named entity 'NOVEL' named entity 'HAVE' named entity 'SEVERE' named entity 'TAUGHT' named entity 'GLOBAL' named entity 'IDEAL' named entity 'REVIEW' named entity 'TO INFECT' named entity 'REFLECT' named entity 'ESTABLISHING' named entity 'CLINICAL SIGNS' named entity 'PATHOLOGY' named entity 'VIRAL REPLICATION' named entity 'PRESENT' named entity 'DIFFERENT' named entity 'DOES NOT' named entity 'CORONAVIRUSES' named entity 'REPRESENT' named entity 'RESPIRATORY INFECTIONS' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'MERS' named entity 'ANIMAL MODELS ' named entity 'SEEN' named entity 'CROSSED' named entity 'INTERNATIONAL' named entity 'CORONAVIRUSES' named entity 'SPECIES' named entity 'STRAINS' named entity 'HUMANS' named entity 'EMERGE' named entity 'CONSIDER' named entity 'ANIMAL MODEL' named entity 'BORDERS' named entity 'FUTURE' named entity 'coronaviruses' named entity 'humans' named entity 'animal' named entity 'MERS-CoV' named entity 'reflect' named entity 'MERS-CoV' named entity 'crossed the species barrier' named entity 'coronaviruses' named entity 'coronaviruses' named entity 'MERS' named entity 'coronavirus' named entity 'lungs' named entity 'signs of disease' named entity 'MERS-CoV' named entity 'clinical disease' named entity 'MERS-CoV' named entity '3, 4' named entity 'viral replication' named entity 'viruses' named entity 'pathogenesis' named entity 'Rag1' named entity 'virus' named entity 'vaccine' named entity 'animal models' named entity 'Transgenic' named entity 'vaccine' named entity 'SARS-CoV' named entity 'Animal models' named entity 'OC43'

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