About: Antiviral Activity of Adenine Arabinoside and Iododeoxyuridine in Human Fetal Intestinal and Tracheal Organ Cultures

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About: Antiviral Activity of Adenine Arabinoside and Iododeoxyuridine in Human Fetal Intestinal and Tracheal Organ Cultures Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral Activity of Adenine Arabinoside and Iododeoxyuridine in Human Fetal Intestinal and Tracheal Organ Cultures
Creator	Dolin, Raphael Smith, Holly
Source	PMC
abstract	In vitro antiviral activities of two potentially clinically useful antiviral compounds, adenine arabinoside and iododeoxyuridine, were examined in human fetal intestinal and tracheal organ cultures infected with Herpesvirus hominis(types I and 2) or vaccinia virus. The two compounds were similarly active against the viruses in organ culture, and minimal inhibitory concentrations could be determined by titration of organ culture fluid harvests into tissue culture or directly in the organ cultures themselves. Minimal inhibitory concentrations were consistently lower in tracheal than in intestinal organ cultures and were consistently higher for H. hoministype 2 than for H. hoministype I. Thus the organ cultures are promising systems in which to evaluate antiviral activity against those agents that replicate in vitro only in organ culture, and they may have particular application to the study of herpetic tracheitis and esophagitis.
has issue date	1975-09-01(xsd:dateTime)
bibo:doi	10.1093/infdis/132.3.287
bibo:pmid	169312
has license	no-cc
sha1sum (hex)	08b0b0f038fca90d96a657e28544bc0aaf2312df
schema:url	https://doi.org/10.1093/infdis/132.3.287
resource representing a document's title	Antiviral Activity of Adenine Arabinoside and Iododeoxyuridine in Human Fetal Intestinal and Tracheal Organ Cultures
has PubMed Central identifier	PMC7109915
has PubMed identifier	169312
schema:publication	J Infect Dis
resource representing a document's body	covid:08b0b0f038fca90d96a657e28544bc0aaf2312df#body_text
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