About: Compartmentalized intrathecal immunoglobulin synthesis during HIV infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Compartmentalized intrathecal immunoglobulin synthesis during HIV infection — A model of chronic CNS inflammation?
Creator	Barroso, Bruno Bonnan, Mickael Demasles, Stéphanie Krim, Elsa Marasescu, Raluca Miquel, Marie
Source	Elsevier; Medline; PMC
abstract	Abstract HIV infects the central nervous system (CNS) during primary infection and persists in resident macrophages. CNS infection initiates a strong local immune response that fails to control the virus but is responsible for by-stander lesions involved in neurocognitive disorders. Although highly active anti-retroviral therapy now offers an almost complete control of CNS viral proliferation, low-grade CNS inflammation persists. This review focuses on HIV-induced intrathecal immunoglobulin (Ig) synthesis. Intrathecal Ig synthesis early occurs in more than three-quarters of patients in response to viral infection of the CNS and persists throughout the course of the disease. Viral antigens are targeted but this specific response accounts for <5% of the whole intrathecal synthesis. Although the nature and mechanisms leading to non-specific synthesis are unknown, this prominent proportion is comparable to that observed in various CNS viral infections. Cerebrospinal fluid-floating antibody-secreting cells account for a minority of the whole synthesis, which mainly takes place in perivascular inflammatory infiltrates of the CNS parenchyma. B-cell traffic and lineage across the blood–brain-barrier have not yet been described. We review common technical pitfalls and update the pending questions in the field. Moreover, since HIV infection is associated with an intrathecal chronic oligoclonal (and mostly non-specific) Ig synthesis and associates with low-grade axonal lesions, this could be an interesting model of the chronic intrathecal synthesis occurring during multiple sclerosis.
has issue date	2015-08-15(xsd:dateTime)
bibo:doi	10.1016/j.jneuroim.2015.05.015
bibo:pmid	26198917
has license	els-covid
sha1sum (hex)	0881c190dedf8b87e07407549365e40229d6b1dd
schema:url	https://doi.org/10.1016/j.jneuroim.2015.05.015
resource representing a document's title	Compartmentalized intrathecal immunoglobulin synthesis during HIV infection — A model of chronic CNS inflammation?
has PubMed Central identifier	PMC7125908
has PubMed identifier	26198917
schema:publication	Journal of Neuroimmunology
resource representing a document's body	covid:0881c190dedf8b87e07407549365e40229d6b1dd#body_text
is schema:about of	named entity 'infects' named entity 'immunoglobulin' named entity 'central nervous system (CNS)' named entity 'targeted' named entity 'chronic' named entity 'technical' named entity 'account' named entity 'multiple sclerosis' named entity 'infection' named entity 'CNS' named entity 'CNS PARENCHYMA' named entity 'RESPONSIBLE' named entity 'ACROSS' named entity 'SPECIFIC' named entity 'EARLY' named entity 'IMMUNOGLOBULIN' named entity 'HIV INFECTION' named entity 'PROMINENT' named entity 'GRADE' named entity 'ANTIBODY' named entity 'IMMUNE RESPONSE' named entity 'HIGHLY ACTIVE ANTI-RETROVIRAL THERAPY' named entity 'SYNTHESIS' named entity 'ASSOCIATED WITH' named entity 'B-CELL' named entity 'TARGETED' named entity 'NATURE' named entity 'INFLAMMATORY' named entity 'AXONAL' named entity 'NON-SPECIFIC' named entity 'PROPORTION' named entity 'CNS INFECTION' named entity 'LOCAL' named entity 'FLOATING' named entity 'SECRETING' named entity 'CNS' named entity 'RESPONSE' named entity 'VIRAL INFECTION' named entity 'MECHANISMS' named entity 'PLACE' named entity 'OBSERVED' named entity 'MULTIPLE SCLEROSIS' named entity 'STRONG' named entity 'REVIEW' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'COURSE' named entity 'PRIMARY INFECTION' named entity 'MODEL OF' named entity 'ALMOST' named entity 'HIV' named entity 'CEREBROSPINAL FLUID' named entity 'CNS INFLAMMATION' named entity 'SYNTHESIS' named entity 'HIV INFECTION' named entity 'HAVE' named entity 'COULD BE' named entity 'ACCOUNT' named entity 'LEADING' named entity 'TRAFFIC' named entity 'INTERESTING' named entity 'DESCRIBED' named entity 'CHRONIC' named entity 'TO CONTROL' named entity 'VIRUS' named entity 'INTRATHECAL' named entity 'BLOOD-BRAIN-BARRIER' named entity 'BUT' named entity 'FAILS' named entity 'RESIDENT' named entity 'INTRATHECAL' named entity 'PENDING' named entity 'COMPLETE' named entity 'INVOLVED' named entity 'UPDATE' named entity 'LINEAGE' named entity 'VARIOUS'

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