About: Dissection and integration of the autophagy signaling network initiated by bluetongue virus infection: crucial candidates ERK1/2, Akt and AMPK

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About: Dissection and integration of the autophagy signaling network initiated by bluetongue virus infection: crucial candidates ERK1/2, Akt and AMPK Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dissection and integration of the autophagy signaling network initiated by bluetongue virus infection: crucial candidates ERK1/2, Akt and AMPK
Creator	Lv, Shuang Sun, En-Cheng Wu, Dong-Lai Xu, Qing-Yuan Zhang, Ji-Kai
Source	PMC
abstract	Bluetongue virus (BTV), a complex double-stranded segmented RNA virus, has been found to initiate cellular autophagy for its own benefit. Here, with a view to understanding the underlying mechanisms, we first systematically dissected the exact signaling network in BTV-induced autophagy. We found that the activity of mTOR, a crucial pivot, was inhibited by BTV1 infection, subsequently leading to downstream p70S6K suppression and autophagy initiation. We then explored the upstream regulators of mTOR and analyzed their activities via a series of assays. We found BTV1-induced autophagy to be independent of the ERK1/2 signaling pathway. However, the BTV1-induced inhibition of PI3K/Akt was found to be partially responsible for mTOR inactivation and subsequent autophagy initiation. Furthermore, we found unexpectedly that AMPK seemed to play a more important role in BTV1-induced autophagy. Elevated [Ca(2+)](cyto)-mediated activation of CaMKKβ exactly managed the activation of AMPK, which then positively regulated autophagy through suppressing mTOR. We must emphasize that TSC2 is a fatal mediator between upstream Akt or AMPK and downstream mTOR through its phosphorylation. Taken together, our data suggested that the BTV1-induced inhibition of the Akt-TSC2-mTOR pathway and the upregulation of the AMPK-TSC2-mTOR pathway both contributed to autophagy initiation and further favored virus replication.
has issue date	2016-03-15(xsd:dateTime)
bibo:doi	10.1038/srep23130
bibo:pmid	26976147
has license	cc-by
sha1sum (hex)	08741b63c08d63c1a86dd3ef3ce3d1bfd39e560b
schema:url	https://doi.org/10.1038/srep23130
resource representing a document's title	Dissection and integration of the autophagy signaling network initiated by bluetongue virus infection: crucial candidates ERK1/2, Akt and AMPK
has PubMed Central identifier	PMC4791558
has PubMed identifier	26976147
schema:publication	Sci Rep
resource representing a document's body	covid:08741b63c08d63c1a86dd3ef3ce3d1bfd39e560b#body_text
is schema:about of	named entity 'autophagy' named entity 'autophagy' named entity 'replication' named entity 'bluetongue virus' named entity 'autophagy' covid:arg/08741b63c08d63c1a86dd3ef3ce3d1bfd39e560b named entity 'autophagy' named entity 'fatal' named entity 'regulated' named entity 'subsequent' named entity 'autophagy' named entity 'activation' named entity 'mTOR' named entity 'AMPK' named entity 'AMPK' named entity 'emphasize' named entity 'Akt' named entity 'mTOR pathway' named entity 'virus replication' named entity 'Bluetongue virus' named entity 'upregulation' named entity 'cyto' named entity 'AMPK' named entity 'AMPK' named entity 'autophagy' named entity 'autophagy' named entity 'autophagy' named entity 'p70S6K' named entity 'bluetongue virus' named entity 'autophagy' named entity 'MAPK' named entity 'virus' named entity 'permeability' named entity 'pathogenicity' named entity 'siNC' named entity 'mTOR' named entity 'cyto' named entity 'mTOR' named entity 'AMPK' named entity 'hepatitis B virus' named entity 'viral infections' named entity 'Cricetulus griseus' named entity 'infection' named entity 'AMPK' named entity 'NS3' named entity 'animal husbandry' named entity 'autophagy' named entity 'mTOR pathway' named entity 'virus' named entity 'viroporin' named entity 'AMP' named entity 'obligate intracellular parasites' named entity 'catabolic process' named entity 'HCV' named entity 'ERK1/2' named entity 'rapamycin' named entity 'autophagy' named entity 'genus' named entity 'Rapamycin' named entity 'lysosomal' named entity 'Akt' named entity 'autophagy' named entity 'life cycles' named entity 'avian reovirus' named entity 'lysosomes' named entity 'PI3K/Akt/mTOR' named entity 'TSC2' named entity '7.2' named entity 'coronavirus' named entity 'NS3' named entity 'TSC2' named entity 'Student's t-test' named entity 'autophagy' named entity 'NSP4' named entity 'Akt' named entity 'hpi' named entity 'upregulation'

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