About: Crystal structure of the C-terminal 2’,5’-phosphodiesterase domain of group A rotavirus protein VP3

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About: Crystal structure of the C-terminal 2’,5’-phosphodiesterase domain of group A rotavirus protein VP3 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Crystal structure of the C-terminal 2’,5’-phosphodiesterase domain of group A rotavirus protein VP3
Creator	Brandmann, Tobias Jinek, Martin
source	Medline; PMC
abstract	In response to viral infections, the mammalian innate immune system induces the production of the second messenger 2’-5’ oligoadenylate (2–5A) to activate latent ribonuclease L (RNase L) that restricts viral replication and promotes apoptosis. A subset of rotaviruses and coronaviruses encode 2’,5’-phosphodiesterase enzymes that hydrolyze 2–5A, thereby inhibiting RNase L activation. We report the crystal structure of the 2’,5’-phosphodiesterase domain of group A rotavirus protein VP3 at 1.39 Å resolution. The structure exhibits a 2H phosphoesterase fold and reveals conserved active site residues, providing insights into the mechanism of 2–5A degradation in viral evasion of host innate immunity.
has issue date	2015-03-25(xsd:dateTime)
bibo:doi	10.1002/prot.24794
bibo:pmid	25758703
has license	green-oa
sha1sum (hex)	082c90a9f4bee280e4582aa439e9d4d046e9fc0a
schema:url	https://doi.org/10.1002/prot.24794
resource representing a document's title	Crystal structure of the C-terminal 2’,5’-phosphodiesterase domain of group A rotavirus protein VP3
has PubMed Central identifier	PMC5068548
has PubMed identifier	25758703
schema:publication	Proteins: Structure, Function, and Bioinformatics
resource representing a document's body	covid:082c90a9f4bee280e4582aa439e9d4d046e9fc0a#body_text
is schema:about of	named entity 'reveals' named entity 'phosphodiesterase' named entity 'rotavirus' named entity 'ROTAVIRUSES' named entity 'STRUCTURE' named entity 'MAMMALIAN' named entity 'MECHANISM' named entity '1.39' named entity 'RNASE L' named entity 'VIRAL REPLICATION' named entity '2C5' named entity 'GROUP A ROTAVIRUS' named entity 'RESPONSE TO' named entity 'INNATE IMMUNITY' named entity 'RESOLUTION' named entity 'ACTIVATE' named entity 'LATENT' named entity 'DOMAIN' named entity 'PHOSPHODIESTERASE' named entity 'CRYSTAL STRUCTURE' named entity 'DOMAIN' named entity 'PROTEIN ' named entity 'ROTAVIRUS PROTEIN' named entity 'VP3' named entity 'C-TERMINAL' named entity 'GROUP A ROTAVIRUS' named entity 'PROVIDING' named entity 'RIBONUCLEASE L' named entity 'REPORT' named entity 'SECOND MESSENGER' named entity '2C5' named entity 'VIRAL INFECTIONS' named entity 'RESTRICTS' named entity 'ACTIVATION' named entity '282' named entity 'FOLD' named entity 'ENZYMES' named entity 'REVEALS' named entity 'VP3' named entity 'OLIGOADENYLATE' named entity 'CORONAVIRUSES' named entity 'PROTEIN ' named entity 'PHOSPHODIESTERASE' named entity 'PRODUCTION' named entity 'ACTIVE SITE' named entity 'CRYSTAL STRUCTURE' named entity 'DEGRADATION' named entity 'SUBSET' named entity 'APOPTOSIS' named entity '2-5A' named entity 'INNATE IMMUNE SYSTEM' named entity 'HOST' named entity 'EXHIBITS' named entity 'CONSERVED' named entity 'INSIGHTS' named entity 'ENCODE' named entity 'VIRAL' named entity 'INHIBITING' named entity 'ROTAVIRUS PROTEIN' named entity 'domain' named entity 'phosphodiesterase' named entity 'RNase L' named entity 'inhibiting' named entity 'RNase' named entity 'hydrolyze' named entity 'crystal structure' named entity 'apoptosis' named entity 'latent ribonuclease' named entity 'innate immunity' named entity 'RNase' named entity 'viral infections' named entity 'Crystal structure' named entity 'UniProt' named entity 'β-sheets' named entity 'enzyme' named entity 'cleavage' named entity 'ligand binding' named entity 'ns2' named entity 'electrostatic' named entity 'innate immune'

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