About: Microbiological findings in bronchoalveolar lavage fluid from lung transplant patients in Sweden

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Microbiological findings in bronchoalveolar lavage fluid from lung transplant patients in Sweden
Creator	Christensson, Bertil Hammarström, Helena Larsson, Hillevi Påhlman, Lisa Aspelund, Anna Hansson, \| Malin Inghammar, \| Friman, Vanda Gerdt, \| Riise, C
Source	Medline; PMC
abstract	BACKGROUND: Lung transplant patients experience a high risk of airway infections and microbial colonization of the lung due to constant exposure to the environment through inhaled microorganisms, denervation, reduced ciliary transport, and decreased cough. METHODS: In this nationwide prospective study on Swedish lung transplant patients, we evaluated the microbiological panorama of bacteria, fungi, and virus found in bronchoalveolar lavage fluid (BALF) obtained the first year after lung transplantation (LTx). Differences in microbiological findings depending of concomitant signs of infection and background factors were assessed. RESULTS: A total of 470 bronchoscopies from 126 patients were evaluated. Sixty‐two percent (n = 293) of BALF samples had positive microbiological finding(s). Forty‐six percent (n = 217) had bacterial growth, 29% (n = 137) fungal growth, and 9% (n = 43) were positive in viral PCR. In 38% of BALF samples (n = 181), a single microbe was found, whereas a combination of bacteria, fungi or virus was found in 24% (n = 112) of bronchoscopies. The most common microbiological findings were Candida albicans, Pseudomonas aeruginosa and coagulase negative Staphylococcus (in 42 (33%), 36 (29%), and 25 (20%) patients, respectively). Microbiological findings were similar in BALF from patients with and without signs of lung infection and the frequency of multidrug resistant (MDR) bacteria was low. No significant association was found between background factors and time to first lung infection. CONCLUSION: This study gives important epidemiologic insights and reinforces that microbiological findings have to be evaluated in the light of clinical symptoms and endobronchial appearance in the assessment of lung infections in lung transplant patients.
has issue date	2018-08-27(xsd:dateTime)
bibo:doi	10.1111/tid.12973
bibo:pmid	30107073
has license	no-cc
sha1sum (hex)	0816e748c473f9ddf03d7952738025c7bf22ef33
schema:url	https://doi.org/10.1111/tid.12973
resource representing a document's title	Microbiological findings in bronchoalveolar lavage fluid from lung transplant patients in Sweden
has PubMed Central identifier	PMC7169803
has PubMed identifier	30107073
schema:publication	Transpl Infect Dis
resource representing a document's body	covid:0816e748c473f9ddf03d7952738025c7bf22ef33#body_text
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