About: Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease

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About: Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease
Creator	Rohde, Gernot Allander, Tobias Arinir, Umut Borg, Irmgard Kronsbein, Juliane Schultze-Werninghaus, Gerhard Hauptmeier, Barbara Ringshausen, Felix Tan, Ai-Yui
Source	Medline; PMC
abstract	OBJECTIVE: Human bocavirus (HBoV) is a recently discovered parvovirus associated with acute respiratory tract infections in children. The objective of the present study was to determine the frequency and clinical relevance of HBoV infection in adult patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD). METHODS: We retrospectively tested 212 COPD patients, 141 (66.5%) with AE-COPD and 71 (33.5%) with stable disease, of whom nasal lavage and induced sputum had been obtained for the presence of HBoV deoxyribonucleic acid (DNA). The specificity of positive polymerase chain reaction results was confirmed by sequencing. RESULTS: Two hundred two of 212 patients for whom PCR results were available both for nasal lavage and induced sputum samples were eligible for data analysis. HBoV DNA was detected in three patients (1.5%). Of those, only one patient had AE-COPD. Thus, the frequency of HBoV infection demonstrated to be low in both AE-COPD (0.8%) and stable COPD (2.9%). HBoV was found in two sputum and one nasal lavage sample in different patients, respectively. Sequencing revealed >99% sequence identity with the reference strain. CONCLUSION: HBoV detection was infrequent. Since we detected HBoV in both upper and lower respiratory tract specimens and in AE-COPD as well as stable disease, a major role of HBoV infection in adults with AE-COPD is unlikely.
has issue date	2009-04-15(xsd:dateTime)
bibo:pmid	19436697
has license	no-cc
sha1sum (hex)	07fe504a3b64db4dd23da77929893eb89215f3be
resource representing a document's title	Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease
has PubMed Central identifier	PMC2672801
has PubMed identifier	19436697
schema:publication	Int J Chron Obstruct Pulmon Dis
resource representing a document's body	covid:07fe504a3b64db4dd23da77929893eb89215f3be#body_text
is schema:about of	named entity 'POLYMERASE CHAIN REACTION' named entity 'PARVOVIRUS' named entity 'PATIENTS' named entity 'STRAIN' named entity 'DEOXYRIBONUCLEIC ACID' named entity 'DIFFERENT' named entity 'SAMPLES' named entity 'ELIGIBLE' named entity 'SPECIMENS' named entity '141' named entity 'UPPER' named entity 'DETECTED' named entity 'STABLE' named entity 'REVEALED' named entity 'DNA' named entity 'CONCLUSION' named entity 'ACUTE' named entity 'IS A' named entity 'DETERMINE' named entity 'infection' named entity 'acute' named entity 'COPD' named entity 'DNA' named entity 'parvovirus' named entity 'ACUTE EXACERBATIONS' named entity 'REFERENCE' named entity 'METHODS' named entity 'TESTED' named entity 'INDUCED SPUTUM' named entity '282' named entity 'SAMPLE' named entity 'DEMONSTRATED' named entity 'ADULTS' named entity 'PRESENT' named entity 'LOW' named entity 'PATIENT' named entity 'ASSOCIATED WITH' named entity 'STUDY' named entity 'CLINICAL RELEVANCE' named entity 'OBJECTIVE' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'FREQUENCY' named entity 'CHRONIC OBSTRUCTIVE PULMONARY DISEASE' named entity 'SEQUENCING' named entity 'SPUTUM' named entity 'LOWER RESPIRATORY TRACT' named entity 'RESULTS' named entity 'POSITIVE' named entity 'A MAJOR' named entity 'INFECTION' named entity 'ROLE' named entity 'RESPIRATORY TRACT INFECTIONS' named entity 'HUMAN BOCAVIRUS INFECTION' named entity 'CLINICAL RELEVANCE' named entity 'SEQUENCE IDENTITY' named entity 'UNLIKELY' named entity 'DATA ANALYSIS' named entity 'CHILDREN' named entity 'CITY' named entity 'INFREQUENT' named entity 'COPD' named entity 'ADULT' named entity 'TWO HUNDRED' named entity 'PCR' named entity 'HUMAN BOCAVIRUS' named entity 'ACUTE EXACERBATION' named entity 'AVAILABLE' named entity '212' named entity 'OBTAINED' named entity 'NASAL LAVAGE' named entity 'RMED' named entity 'RECENTLY' named entity 'FREQUENCY' named entity 'STABLE DISEASE' named entity 'DETECTION'

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