About: Preventive Effect of Hochu-ekki-to on Lipopolysaccharide-Induced Acute Lung Injury in BALB/c Mice

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About: Preventive Effect of Hochu-ekki-to on Lipopolysaccharide-Induced Acute Lung Injury in BALB/c Mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Preventive Effect of Hochu-ekki-to on Lipopolysaccharide-Induced Acute Lung Injury in BALB/c Mice
Creator	Ae, Bando Ae, Gejyo Ae, Ohno Ae, Takada Bando, Ae Fumitake, A Gejyo, Ae Masashi, A Moriyama, Ae Moriyama, Hiroshi Ohno, Ae Shoji, A Sugiyama, Ae Sugiyama, Yukihiko Suzuki, Ae Suzuki, Eiichi Tajima, S Tajima, Shunji Takada, Ae Toshinori, A Yamasawa, Ae Yamasawa, Hideaki
Source	PMC
abstract	This study was designed to investigate the effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, on the development of lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. ALI was induced in female BALB/c mice by the intranasal administration of 0.1 mg/kg LPS. The mice were divided into a group receiving normal feed and another group receiving feed mixed with TJ-41 at a dose of 1 g/kg/day for 8 weeks before LPS challenge. In the bronchoalveolar lavage fluid, the preadministration of TJ-41 caused significant reduction in the absolute number of total cells, neutrophils, and macrophages. The preadministration of TJ-41 significantly inhibited increases in the serum level of keratinocyte chemoattractant (KC), which is a murine chemotaxin for neutrophils that corresponds to human interleukin-8, with respect to its concentration at 24 h after LPS challenge. Furthermore, the histopathologic findings indicated that alveolitis with leukocyte infiltration in the alveolar space was less severe in the TJ-41-treated mice than in the control mice. These findings indicated that the preadministration of TJ-41 could show an inhibitory effect on ALI in this experimental murine system associated with the suppression of chemokine production.
has issue date	2006-11-03(xsd:dateTime)
bibo:doi	10.1007/s00408-006-0018-z
bibo:pmid	17086464
has license	no-cc
sha1sum (hex)	076a4efc053789c9550341e247a9e5a273cd4c26
schema:url	https://doi.org/10.1007/s00408-006-0018-z
resource representing a document's title	Preventive Effect of Hochu-ekki-to on Lipopolysaccharide-Induced Acute Lung Injury in BALB/c Mice
has PubMed Central identifier	PMC7101655
has PubMed identifier	17086464
schema:publication	Lung
resource representing a document's body	covid:076a4efc053789c9550341e247a9e5a273cd4c26#body_text
is schema:about of	named entity 'day' named entity 'LPS' named entity 'system' named entity 'LPS' named entity 'interleukin' named entity 'murine' named entity 'Preventive' named entity 'FINDINGS' named entity 'MG%' named entity 'KERATINOCYTE' named entity 'MICE' named entity 'CHEMOATTRACTANT' covid:arg/076a4efc053789c9550341e247a9e5a273cd4c26 named entity 'space' named entity 'study' named entity 'cells' named entity 'receiving' named entity 'ALI' named entity 'neutrophils' named entity 'human' named entity 'Lung' named entity 'acute lung injury' named entity 'alveolitis' named entity 'interleukin-8' named entity 'herbal medicine' named entity 'ALI' named entity 'mice' named entity 'murine' named entity 'LPS' named entity 'mice' named entity 'mice' named entity 'Preventive Effect' named entity 'Mice' named entity 'Acute Lung Injury' named entity 'lung inflammation' named entity 'ALI' named entity 'animal experiments' named entity 'histopathologic' named entity 'performed on animals' named entity 'neutrophils' named entity 'LPS' named entity 'neutrophils' named entity 'respiratory failure' named entity 'influenza virus' named entity 'endothelium' named entity 'mice' named entity 'influenza virus' named entity 'LPS' named entity 'ROS' named entity 'LPS' named entity 'neutrophils' named entity 'ALI' named entity 'BALF' named entity 'herbal medicines' named entity 'decoction' named entity 'neutrophils' named entity 'critically ill patients' named entity 'mice' named entity 'serum' named entity 'alveolar'

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