About: Isolation of and Characterization of Neutralizing Antibodies to Covid-19 from a Large Human Naïve scFv Phage Display Library

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About: Isolation of and Characterization of Neutralizing Antibodies to Covid-19 from a Large Human Naïve scFv Phage Display Library Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Isolation of and Characterization of Neutralizing Antibodies to Covid-19 from a Large Human Naïve scFv Phage Display Library
Creator	Yuan, Andy Zhen, Shanshan Chen, Xiaojun Bai, Lili Guo, Daqing Li, Yanhu Meng, Qingwu Wen, Zhenguo Xue, ，xiaoying Yang, ，ji Zhao, Likun
Source	BioRxiv
abstract	SARS-CoV-2 (Covid-19) has caused currently ongoing global plague and imposed great challenges to health managing systems all over the world, with millions of infections and hundreds of thousands of deaths. In addition to racing to develop vaccines, neutralizing antibodies (nAbs) to this virus have been extensively sought and are expected to provide another prevention and therapy tool against this frantic pandemic. To offer fast isolation and shortened early development, a large human naïve phage display antibody library, was built and used to screen specific nAbs to the receptor-binding domain, RBD, the key for Covid-19 virus entry through a human receptor, ACE2. The obtained RBD-specific antibodies were characterized by epitope mapping, FACS and neutralization assay. Some of the antibodies demonstrated spike-neutralizing property and ACE2-competitiveness. Our work proved that RBD-specific neutralizing binders from human naïve antibody phage display library are promising candidates to for further Covid-19 therapeutics development.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.1101/2020.05.19.104281
has license	biorxiv
sha1sum (hex)	075de2d475666fb451d348f197cbce139bb6540d
schema:url	https://doi.org/10.1101/2020.05.19.104281
resource representing a document's title	Isolation of and Characterization of Neutralizing Antibodies to Covid-19 from a Large Human Naïve scFv Phage Display Library
schema:publication	bioRxiv
resource representing a document's body	covid:075de2d475666fb451d348f197cbce139bb6540d#body_text
is schema:about of	named entity 'Some' named entity 'Covid-19' named entity 'SARS-CoV-2' named entity 'expected' named entity 'phage display' named entity 'managing' named entity 'TOOL' named entity 'SPIKE' named entity 'CHALLENGES' named entity 'EXPECTED' named entity 'WORLD' named entity 'FACS' named entity 'DEMONSTRATED' named entity 'NEUTRALIZING ANTIBODIES' named entity 'ANTIBODY' named entity 'VIRUS' named entity 'OBTAINED' named entity 'USED' named entity 'GREAT' named entity 'EPITOPE MAPPING' named entity 'INFECTIONS' named entity 'antibodies' named entity 'extensively' named entity 'vaccines' named entity 'library' named entity 'hundreds' named entity 'phage display' named entity 'Characterization' named entity 'RBD' named entity 'FACS' named entity 'assay' named entity 'antibody' named entity 'Neutralizing Antibodies' named entity 'IgG' named entity 'antibody' named entity 'antibodies' named entity 'RBD' named entity 'virus' named entity 'RBD' named entity 'cut and paste' named entity 'scFv' named entity 'RBD' named entity 'MERS-CoV' named entity 'membrane fusion' named entity 'SARS' named entity 'titer' named entity 'phagemid' named entity 'quarantine' named entity 'coronavirus' named entity 'antibody' named entity 'spike proteins' named entity 'Covid-19' named entity 'antibodies' named entity 'genomic sequences' named entity 'Covid' named entity 'RBDs' named entity 'antibodies' named entity 'FITC' named entity 'vaccine' named entity 'immunogenic' named entity 'ACE2' named entity 'size exclusion chromatography' named entity 'phage display' named entity 'antibody' named entity 'Gel Extraction' named entity 'neutralizing antibody' named entity 'Fujian Medical University' named entity 'glycosylation' named entity 'antibodies' named entity 'E. coli' named entity 'phage display library' named entity 'RBD' named entity 'glycerol' named entity 'Philippines'

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