About: Regulatory Role of Small Nucleolar RNAs in Human Diseases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulatory Role of Small Nucleolar RNAs in Human Diseases
Creator	Komissarov, Andrey Filippova, Julia Kuligina, Elena Richter, Vladimir Semenov, Dmitry Stepanov, Grigory
Source	Medline; PMC
abstract	Small nucleolar RNAs (snoRNAs) are appreciable players in gene expression regulation in human cells. The canonical function of box C/D and box H/ACA snoRNAs is posttranscriptional modification of ribosomal RNAs (rRNAs), namely, 2′-O-methylation and pseudouridylation, respectively. A series of independent studies demonstrated that snoRNAs, as well as other noncoding RNAs, serve as the source of various short regulatory RNAs. Some snoRNAs and their fragments can also participate in the regulation of alternative splicing and posttranscriptional modification of mRNA. Alterations in snoRNA expression in human cells can affect numerous vital cellular processes. SnoRNA level in human cells, blood serum, and plasma presents a promising target for diagnostics and treatment of human pathologies. Here we discuss the relation between snoRNAs and oncological, neurodegenerative, and viral diseases and also describe changes in snoRNA level in response to artificial stress and some drugs.
has issue date	2015-04-28(xsd:dateTime)
bibo:doi	10.1155/2015/206849
bibo:pmid	26060813
has license	cc-by
sha1sum (hex)	07420d39191900a262a4c5afff61e0ef80eac575
schema:url	https://doi.org/10.1155/2015/206849
resource representing a document's title	Regulatory Role of Small Nucleolar RNAs in Human Diseases
has PubMed Central identifier	PMC4427830
has PubMed identifier	26060813
schema:publication	Biomed Res Int
resource representing a document's body	covid:07420d39191900a262a4c5afff61e0ef80eac575#body_text
is schema:about of	named entity 'HUMAN DISEASES' named entity 'SnoRNA' named entity 'drugs' named entity 'presents' named entity 'BLOOD SERUM' covid:arg/07420d39191900a262a4c5afff61e0ef80eac575 named entity 'EXPRESSION' named entity 'REGULATION' named entity 'THEIR' named entity 'BOX' named entity 'SMALL NUCLEOLAR RNAS' named entity 'GENE EXPRESSION REGULATION' named entity 'STUDIES' named entity 'HUMAN' named entity 'O-METHYLATION' named entity 'RESPONSE TO' named entity 'CELLULAR PROCESSES' named entity 'ALTERATIONS' named entity 'NUMEROUS' named entity 'SNORNA' named entity 'AFFECT' named entity 'SERVE' named entity 'TARGET' named entity 'CHANGES' named entity 'DISCUSS' named entity 'REGULATORY ROLE' named entity 'PATHOLOGIES' named entity 'SERIES' named entity 'RELATION' named entity 'PRESENTS' named entity 'RNAS' named entity 'DESCRIBE' named entity 'SHORT' named entity 'LEVEL' named entity 'FRAGMENTS' named entity 'REGULATORY' named entity 'DRUGS' named entity 'DIAGNOSTICS' named entity 'OF INDEPENDENT' named entity 'PLAYERS' named entity 'HUMAN CELLS' named entity 'MRNA' named entity 'SMALL NUCLEOLAR RNAS' named entity 'HERE' named entity 'SOURCE' named entity 'ARTIFICIAL' named entity 'RIBOSOMAL' named entity 'FUNCTION' named entity 'POSTTRANSCRIPTIONAL MODIFICATION' named entity 'VARIOUS' named entity 'PSEUDOURIDYLATION' named entity 'ALTERNATIVE SPLICING' named entity 'PLASMA' named entity 'VITAL' named entity 'DEMONSTRATED' named entity 'VIRAL DISEASES' named entity 'STRESS' named entity 'TREATMENT' named entity 'participate' named entity 'short' named entity 'snoRNAs' named entity 'Some' named entity 'oncological' named entity 'cellular processes' named entity 'human cells' named entity 'Here' named entity 'pathologies' named entity 'promising' named entity 'neurodegenerative' named entity 'gene' named entity 'RNAs' named entity 'gene expression regulation' named entity 'posttranscriptional' named entity 'Small nucleolar RNAs' named entity 'blood serum' named entity 'cellular processes'

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