About: Evaluation of a recombinant measles virus expressing hepatitis C virus envelope proteins by infection of human PBL-NOD/Scid/Jak3null mouse

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About: Evaluation of a recombinant measles virus expressing hepatitis C virus envelope proteins by infection of human PBL-NOD/Scid/Jak3null mouse Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evaluation of a recombinant measles virus expressing hepatitis C virus envelope proteins by infection of human PBL-NOD/Scid/Jak3null mouse
Creator	Kohara, Michinori Tsukiyama-Kohara, Kyoko Kai, Chieko Satoh, Masaaki Harada, Shinji Iwanaga, Sumako Okada, Seiji Saito, Makoto Seki, Takahiro Tanaka, Kohsuke Ali, Salem Elwy, Salem
Source	Elsevier; Medline; PMC
abstract	Abstract In this study, we infected NOD/Scid/Jak3null mice engrafted human peripheral blood leukocytes (hu-PBL-NOJ) with measles virus Edmonston B strain (MV-Edm) expressing hepatitis C virus (HCV) envelope proteins (rMV-E1E2) to evaluate the immunogenicity as a vaccine candidate. Although human leukocytes could be isolated from the spleen of mock-infected mice during the 2-weeks experiment, the proportion of engrafted human leukocytes in mice infected with MV (103–105 pfu) or rMV-E1E2 (104 pfu) was decreased. Viral infection of the splenocytes was confirmed by the development of cytopathic effects (CPEs) in co-cultures of splenocytes and B95a cells and verified using RT-PCR. Finally, human antibodies against MV were more frequently observed than E2-specific antibodies in serum from mice infected with a low dose of virus (MV, 100–101 pfu, and rMV-E1E2, 101–102 pfu). These results showed the possibility of hu-PBL-NOJ mice for the evaluation of the immunogenicity of viral proteins.
has issue date	2010-12-31(xsd:dateTime)
bibo:doi	10.1016/j.cimid.2010.02.006
bibo:pmid	20299097
has license	els-covid
sha1sum (hex)	071017f2154249040bf73e9e5940b54d49221e1b
schema:url	https://doi.org/10.1016/j.cimid.2010.02.006
resource representing a document's title	Evaluation of a recombinant measles virus expressing hepatitis C virus envelope proteins by infection of human PBL-NOD/Scid/Jak3null mouse
has PubMed Central identifier	PMC7112578
has PubMed identifier	20299097
schema:publication	Comparative Immunology, Microbiology and Infectious Diseases
resource representing a document's body	covid:071017f2154249040bf73e9e5940b54d49221e1b#body_text
is schema:about of	named entity 'Edmonston' named entity 'isolated' named entity 'pfu' named entity 'proportion' named entity 'measles virus' named entity 'expressing' named entity 'LOW DOSE' named entity 'VIRUS' named entity 'DECREASED' named entity 'NOD' named entity 'COCULTURES' named entity 'ANTIBODIES' named entity 'B95A' named entity 'MICE' named entity 'EXPERIMENT' named entity 'SPLENOCYTES' named entity 'LEUKOCYTES' named entity 'VACCINE CANDIDATE' named entity 'VERIFIED' named entity 'INFECTION' named entity 'NOD' named entity 'PROTEINS' named entity 'EDM' named entity 'DEVELOPMENT' named entity 'INFECTED' named entity 'HUMAN' named entity 'PBL' named entity 'EVALUATION' named entity 'MEASLES VIRUS' named entity 'MOUSE' named entity 'PFU' named entity 'EVALUATE' named entity 'FREQUENTLY' named entity 'BLOOD LEUKOCYTES' named entity 'STRAIN' named entity 'IMMUNOGENICITY' named entity 'SERUM' named entity 'CELLS' named entity 'OBSERVED' named entity 'MEASLES VIRUS' named entity 'RESULTS' named entity 'EVALUATION' named entity 'MOCK' named entity 'VIRUS ENVELOPE PROTEINS' named entity 'SPLEEN' named entity 'HEPATITIS C VIRUS' named entity 'USING' named entity 'COULD BE' named entity 'CONFIRMED BY' named entity 'SPECIFIC' named entity 'ISOLATED' named entity 'VIRAL INFECTION' named entity 'PROPORTION' named entity 'ENVELOPE' named entity 'VIRAL PROTEINS' named entity 'RECOMBINANT' named entity 'RT-PCR' named entity 'THESE' named entity 'HEPATITIS C VIRUS' named entity 'STUDY' named entity 'PERIPHERAL BLOOD' named entity 'HUMAN' named entity 'CYTOPATHIC EFFECTS' named entity 'PBL' named entity 'WEEKS' covid:arg/071017f2154249040bf73e9e5940b54d49221e1b named entity 'HCV' named entity 'Viral infection' named entity 'development' named entity 'human'

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