About: A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs

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About: A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs
Creator	Bu, Zhigao Liu, Renqiang Wen, Zhiyuan Li, Fang Chen, Weiye Wang, Xijun Zhang, Jiwen Zhang, Xianfeng Shan, Dan He, Xijun Guan, Yuntao Zhao, Dongming Chen, Hefeng Liu, Jinxiong Wang, Lulu Wang, Zilong
Source	PMC
abstract	African swine fever (ASF) is a devastating infectious disease in swine that is severely threatening the global pig industry. An efficacious vaccine is urgently required. Here, we used the Chinese ASFV HLJ/18 as a backbone and generated a series of gene-deleted viruses. The virulence, immunogenicity, safety, and protective efficacy evaluation in specific-pathogen-free pigs, commercial pigs, and pregnant sows indicated that one virus, namely HLJ/18-7GD, which has seven genes deleted, is fully attenuated in pigs, cannot convert to the virulent strain, and provides complete protection of pigs against lethal ASFV challenge. Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV, and as such is expected to play an important role in controlling the spread of ASFV. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s11427-020-1657-9 and is accessible for authorized users.
has issue date	2020-03-01(xsd:dateTime)
bibo:doi	10.1007/s11427-020-1657-9
bibo:pmid	32124180
has license	no-cc
sha1sum (hex)	06de213066d598f02f343fff945179d90ad8f734
schema:url	https://doi.org/10.1007/s11427-020-1657-9
resource representing a document's title	A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs
has PubMed Central identifier	PMC7223596
has PubMed identifier	32124180
schema:publication	Sci China Life Sci
resource representing a document's body	covid:06de213066d598f02f343fff945179d90ad8f734#body_text
is schema:about of	named entity 'virus' named entity 'vaccine strain' named entity 'lymph nodes' named entity 'viral DNA' named entity 'virus' named entity 'lymph node' named entity 'SPF' named entity 'China' named entity 'viral DNA' named entity 'ASFV' named entity 'viruses' named entity 'Georgia' named entity 'virulent' named entity 'farmed pigs' named entity 'HVRI' named entity 'pregnancy' named entity 'lymph node' named entity 'gene' named entity 'immunogenic' named entity 'viral genome' named entity 'kidney' named entity 'SPF' named entity 'supernatants' named entity 'pseudorabies virus' named entity 'China' named entity 'biosafety level 3' named entity 'viral DNA' named entity 'gestation' named entity 'ASFV' named entity 'Harbin Veterinary Research Institute' named entity 'lymph nodes' named entity 'inoculation' named entity 'Applied Biosystems' named entity 'gene' named entity 'thymus' named entity 'gestation' named entity 'pregnancy' named entity 'viral DNA' named entity 'viral DNA' named entity 'lung' named entity 'spleen' named entity 'viral DNA' named entity 'SPF' named entity 'spleen' named entity 'ASFV' named entity 'China' named entity 'viral DNA' named entity 'China' named entity 'culling' named entity 'viral DNA' named entity 'viruses' named entity 'PRRS' named entity 'virus' named entity 'lymph nodes' named entity 'tonsil' named entity '21 days' named entity 'virus' named entity 'fever' named entity 'inoculation' named entity 'ASFV' named entity 'qPCR' named entity 'attenuated vaccine' named entity 'double-stranded DNA' named entity 'transfection' named entity 'inoculation' named entity 'adenovirus'

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