About: The dimer interface of the SARS coronavirus nucleocapsid protein adapts a porcine respiratory and reproductive syndrome virus-like structure

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About: The dimer interface of the SARS coronavirus nucleocapsid protein adapts a porcine respiratory and reproductive syndrome virus-like structure Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The dimer interface of the SARS coronavirus nucleocapsid protein adapts a porcine respiratory and reproductive syndrome virus-like structure
Creator	Chang, Chung-Ke Huang, Tai-Huang Chang, Chi-Fon Chiang, Yen-Chieh Hsieh, Chiu-Min Sue, Shih-Che Tsai, Cheng-Kun Wu, Wen-Jin De La Rosa, Miguel Hsiao, Hsin-Hao Lee, Shin-Jye Yu, Tsan-Hung
Source	Elsevier; Medline; PMC
abstract	We have employed NMR to investigate the structure of SARS coronavirus nucleocapsid protein dimer. We found that the secondary structure of the dimerization domain consists of five α helices and a β-hairpin. The dimer interface consists of a continuous four-stranded β-sheet superposed by two long α helices, reminiscent of that found in the nucleocapsid protein of porcine respiratory and reproductive syndrome virus. Extensive hydrogen bond formation between the two hairpins and hydrophobic interactions between the β-sheet and the α helices render the interface highly stable. Sequence alignment suggests that other coronavirus may share the same structural topology.
has issue date	2005-10-24(xsd:dateTime)
bibo:doi	10.1016/j.febslet.2005.09.038
bibo:pmid	16214138
has license	no-cc
sha1sum (hex)	06c068c68b80eaea851387c1d9a8f2ca00002105
schema:url	https://doi.org/10.1016/j.febslet.2005.09.038
resource representing a document's title	The dimer interface of the SARS coronavirus nucleocapsid protein adapts a porcine respiratory and reproductive syndrome virus-like structure
has PubMed Central identifier	PMC7094587
has PubMed identifier	16214138
schema:publication	FEBS Lett
resource representing a document's body	covid:06c068c68b80eaea851387c1d9a8f2ca00002105#body_text
is schema:about of	named entity 'PROTEIN ' named entity 'SARS CORONAVIRUS' named entity 'SHEET' named entity 'NUCLEOCAPSID PROTEIN' named entity 'STABLE' named entity 'SARS CORONAVIRUS' named entity 'HIGHLY' named entity 'STRUCTURE' named entity 'SEQUENCE ALIGNMENT' named entity 'EXTENSIVE' covid:arg/06c068c68b80eaea851387c1d9a8f2ca00002105 named entity 'TOPOLOGY' named entity 'SHARE' named entity 'CORONAVIRUS' named entity 'TO INVESTIGATE' named entity 'HYDROGEN BOND' named entity 'INTERACTIONS' named entity 'STRUCTURE' named entity 'INTERFACE' named entity 'RENDER' named entity 'SECONDARY STRUCTURE' named entity 'DIMER' named entity 'PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS' named entity 'LIKE' named entity 'NUCLEOCAPSID PROTEIN' named entity 'PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS' named entity 'HELICES' named entity 'CONTINUOUS' named entity 'EMPLOYED' named entity 'DOMAIN' named entity 'HYDROPHOBIC' named entity 'NMR' named entity 'INTERFACE' named entity 'DIMER' named entity 'STRUCTURAL' named entity 'FORMATION' named entity 'DIMERIZATION' named entity 'FOUND' named entity 'PROTEIN ' named entity 'LONG' named entity 'HAVE' named entity 'NMR' named entity 'SARS coronavirus' named entity 'hydrophobic interactions' named entity 'hydrogen bond' named entity 'nucleocapsid protein' named entity 'secondary structure' named entity 'dimerization' named entity 'porcine' named entity 'nucleocapsid protein' named entity 'nucleocapsid protein' named entity 'virus' named entity 'porcine' named entity 'dimer' named entity 'Protein' named entity 'dimer' named entity 'NaCl' named entity 'porcine' named entity 'monomers' named entity 'cross-linker' named entity 'viruses' named entity 'hydrophobic interactions' named entity 'Protein' named entity 'triple-resonance' named entity 'SARS-CoV' named entity 'protein' named entity 'dimer' named entity 'nucleocapsid proteins' named entity 'coronavirus' named entity 'NMR'

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