About: Platelets and Infection – An Emerging Role of Platelets in Viral Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Platelets and Infection – An Emerging Role of Platelets in Viral Infection
Creator	Assinger, Alice Garraud, Olivier Shen, Bo
Source	Medline; PMC
abstract	Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis. While platelet activation and elevated platelet counts (thrombocytosis) are associated with increased risk of thrombotic complications, low platelet counts (thrombocytopenia) and several platelet function disorders increase the risk of bleeding. Over the last years, more and more evidence has emerged that platelets and their activation state can also modulate innate and adaptive immune responses and low platelet counts have been identified as a surrogate marker for poor prognosis in septic patients. Viral infections often coincide with platelet activation. Host inflammatory responses result in the release of platelet activating mediators and a pro-oxidative and pro-coagulant environment, which favors platelet activation. However, viruses can also directly interact with platelets and megakaryocytes and modulate their function. Furthermore, platelets can be activated by viral antigen–antibody complexes and in response to some viruses B-lymphocytes also generate anti-platelet antibodies. All these processes contributing to platelet activation result in increased platelet consumption and removal and often lead to thrombocytopenia, which is frequently observed during viral infection. However, virus-induced platelet activation does not only modulate platelet count but also shape immune responses. Platelets and their released products have been reported to directly and indirectly suppress infection and to support virus persistence in response to certain viruses, making platelets a double-edged sword during viral infections. This review aims to summarize the current knowledge on platelet interaction with different types of viruses, the viral impact on platelet activation, and platelet-mediated modulations of innate and adaptive immune responses.
has issue date	2014-12-18(xsd:dateTime)
bibo:doi	10.3389/fimmu.2014.00649
bibo:pmid	25566260
has license	cc-by
sha1sum (hex)	06b3f93a98def37bdbfa4487060cd836fdf1070d
schema:url	https://doi.org/10.3389/fimmu.2014.00649
resource representing a document's title	Platelets and Infection – An Emerging Role of Platelets in Viral Infection
has PubMed Central identifier	PMC4270245
has PubMed identifier	25566260
schema:publication	Front Immunol
resource representing a document's body	covid:06b3f93a98def37bdbfa4487060cd836fdf1070d#body_text
is schema:about of	named entity 'INFECTION' named entity 'ROLE' named entity 'VIRAL INFECTION' named entity 'PLATELETS' named entity 'viral infection' named entity 'progenitor cells' named entity 'platelet' named entity 'platelets' named entity 'Junin virus' named entity 'CLEC-2' named entity 'HCV' named entity 'feedback mechanisms' named entity 'plasma' named entity 'HIV' named entity 'T-helper' named entity 'lung diseases' named entity 'infection' named entity 'platelet count' named entity 'protein subunit' named entity 'DC-SIGN' named entity 'dense granules' named entity 'Coxsackie' named entity 'infection' named entity 'talin' named entity 'platelet' named entity 'Encephalomyocarditis virus' named entity 'platelet' named entity 'CD154' named entity 'apoptosis' named entity 'Platelets' named entity 'platelets' named entity 'virus infections' named entity 'CCL5' named entity 'T-lymphocyte' named entity 'liver tissue' named entity 'macrophages' named entity 'platelet' named entity 'IL-6' named entity 'chromosomes' named entity 'liver' named entity 'thrombi' named entity 'liver tissue' named entity 'CD61' named entity 'c-Mpl' named entity 'circulating tumor cells' named entity 'pathogen' named entity 'HIV' named entity 'platelet' named entity 'coagulation cascade' named entity 'cardiovascular disease' named entity 'Platelets' named entity 'megakaryocytes' named entity 'atherosclerotic plaques' named entity 'CXCL4' named entity 'hemostasis' named entity 'platelet activation' named entity 'viral infections' named entity 'Platelet' named entity 'CCL5' named entity 'platelet' named entity 'germinal center' named entity 'hepatitis virus' named entity 'endothelial cells' named entity 'collagen receptor' named entity 'CCL5' named entity 'Megakaryocyte' named entity 'Platelets' named entity 'platelet' named entity 'NS-1' named entity 'viruses' named entity 'viral infections' named entity 'platelet' named entity 'Platelets' named entity 'megakaryocytes' named entity 'megakaryocytes' named entity 'TLR' named entity 'platelet' named entity 'thrombocytopenia' named entity 'platelet activation'

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