About: Antiviral Protection by IFITM3 In Vivo

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral Protection by IFITM3 In Vivo
Creator	Zani, Ashley Yount, Jacob
Source	Medline; PMC
abstract	PURPOSE OF REVIEW: Interferon-induced transmembrane protein 3 (IFITM3) is a cellular restriction factor that blocks fusion between virus and host membranes. Here, we provide an introduction to IFITM3 and the biochemical regulation underlying its antiviral activity. Further, we analyze and summarize the published literature examining phenotypes of IFITM3 knockout mice upon infections with viral pathogens and discuss the controversial association between single nucleotide polymorphisms (SNPs) in the human IFITM3 gene and severe virus infections. RECENT FINDINGS: Recent publications show that IFITM3 knockout mice experience more severe pathologies than wild-type mice in diverse virus infections, including infections with influenza A virus, West Nile virus, Chikungunya virus, Venezuelan equine encephalitis virus, respiratory syncytial virus, and cytomegalovirus. Likewise, numerous studies of humans of Chinese ancestry have associated the IFITM3 SNP rs12252-C with severe influenza virus infections, though examinations of other populations, such as Europeans, in which this SNP is rare, have largely failed to identify an association with severe infections. A second SNP, rs34481144-A, found in the human IFITM3 promoter has also recently been reported to be a risk allele for severe influenza virus infections. SUMMARY: There is significant evidence for a protective role of IFITM3 against virus infections in both mice and humans, though additional work is required to identify the range of pathogens restricted by IFITM3 and the mechanisms by which human SNPs affect IFITM3 levels or functionality.
has issue date	2018-08-03(xsd:dateTime)
bibo:doi	10.1007/s40588-018-0103-0
bibo:pmid	30662816
has license	cc-by
sha1sum (hex)	069d6ce905dc7992f5bc8692218ca3969ab3e227
schema:url	https://doi.org/10.1007/s40588-018-0103-0
resource representing a document's title	Antiviral Protection by IFITM3 In Vivo
has PubMed Central identifier	PMC6334760
has PubMed identifier	30662816
schema:publication	Curr Clin Microbiol Rep
resource representing a document's body	covid:069d6ce905dc7992f5bc8692218ca3969ab3e227#body_text
is schema:about of	named entity 'PROTECTION' named entity 'IFITM3' named entity 'DISCUSS' named entity 'HOST' named entity 'MEMBRANES' named entity 'CELLULAR' named entity 'FACTOR' named entity 'ANTIVIRAL' named entity 'PROVIDE' named entity 'VIRUS' named entity 'IFITM3' named entity 'REGULATION' named entity 'PUBLISHED' named entity 'VIRAL PATHOGENS' named entity 'INTRODUCTION' named entity 'SINGLE NUCLEOTIDE POLYMORPHISMS' named entity 'EXAMINING' named entity 'GENE' named entity 'BLOCKS' named entity 'FUSION' named entity 'HERE' named entity 'PUBLIC' named entity 'SEVERE' named entity 'INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 3' named entity 'RESTRICTION' covid:arg/069d6ce905dc7992f5bc8692218ca3969ab3e227 named entity 'PHENOTYPES' named entity 'ITS' named entity 'BIOCHEMICAL' named entity 'HHS' named entity 'IN VIVO' named entity 'ACCESS' named entity 'PURPOSE' named entity 'INFECTIONS' named entity 'REVIEW' named entity 'IS A' named entity 'LITERATURE' named entity 'UNDERLYING' named entity 'KNOCKOUT MICE' named entity 'HUMAN' named entity 'ASSOCIATION' named entity 'ANTIVIRAL ACTIVITY' named entity 'knockout mice' named entity 'IFITM3' named entity 'IFITM3' named entity 'IFITM3' named entity 'restriction factor' named entity 'mice' named entity 'pathogenicity' named entity 'antiviral' named entity 'antiviral activity' named entity 'IFITM3' named entity 'low pH' named entity 'IFITM3' named entity 'cell types' named entity 'knock-down' named entity 'virus replication' named entity 'influenza virus' named entity 'IFITM3' named entity 'mice' named entity 'IFITM3' named entity 'gene splicing' named entity 'CD8 T cells' named entity 'IFITM3' named entity 'virus' named entity 'phosphatases' named entity 'restriction factor' named entity 'infection' named entity 'virus' named entity 'IFITM3' named entity 'virions' named entity 'knockout mice' named entity 'cell membranes' named entity 'sequenced' named entity 'SNP' named entity 'ZDHHC3' named entity 'highly conserved' named entity 'mice' named entity 'weight loss' named entity 'spinal cord'

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