About: ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

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About: ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)
Creator	Lu, Qing Srivastava, Anup Srivastava, • Lu, • Black, Stephen Black, • Kellner, M Kellner, Manuela Noonepalle, Satish Noonepalle, • Zemskov, Evgeny Zemskov, •
Source	PMC
abstract	The generation of reactive oxygen species (ROS) plays an important role for the maintenance of cellular processes and functions in the body. However, the excessive generation of oxygen radicals under pathological conditions such as acute lung injury (ALI) and its most severe form acute respiratory distress syndrome (ARDS) leads to increased endothelial permeability. Within this hallmark of ALI and ARDS, vascular microvessels lose their junctional integrity and show increased myosin contractions that promote the migration of polymorphonuclear leukocytes (PMNs) and the transition of solutes and fluids in the alveolar lumen. These processes all have a redox component, and this chapter focuses on the role played by ROS during the development of ALI/ARDS. We discuss the origins of ROS within the cell, cellular defense mechanisms against oxidative damage, the role of ROS in the development of endothelial permeability, and potential therapies targeted at oxidative stress.
has issue date	2017-10-18(xsd:dateTime)
bibo:doi	10.1007/978-3-319-63245-2_8
bibo:pmid	29047084
has license	no-cc
sha1sum (hex)	06906292927b54ef61b68fbe689965730726813a
schema:url	https://doi.org/10.1007/978-3-319-63245-2_8
resource representing a document's title	ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)
has PubMed Central identifier	PMC7120947
has PubMed identifier	29047084
schema:publication	Pulmonary Vasculature Redox Signaling in Health and Disease
resource representing a document's body	covid:06906292927b54ef61b68fbe689965730726813a#body_text
is schema:about of	named entity 'Pulmonary' named entity 'Signaling' named entity 'Redox' named entity 'endothelial' named entity 'receptor for advanced glycation endproducts' named entity 'electrons' named entity 'TJs' named entity 'sheep' named entity 'high levels' named entity 'pathological conditions' named entity 'randomized trial' named entity 'VE-cadherin' named entity 'hypoxemia' named entity 'GSSG' named entity 'cytotoxic agents' named entity 'redox' named entity 'bioavailability' named entity 'NOX3' named entity 'ERK' named entity 'Cdc42' named entity 'pulmonary edema' named entity 'pro-inflammatory cytokines' named entity 'animal model' named entity 'conformation' named entity 'transendothelial migration' named entity 'Proteomic' named entity 'NF-κB' named entity 'Rho' named entity 'actin cytoskeleton' named entity 'ROS' named entity 'endothelial' named entity 'lung inflammation' named entity 'ortho' named entity 'oxygen' named entity 'neutrophil' named entity 'hyperoxia' named entity 'oxidative stress' named entity 'tissue distribution' named entity 'myosin' named entity 'phosphorylation' named entity 'isoforms' named entity 'ARDS' named entity 'cofactor' named entity 'Reduced oxygen' named entity 'MnSOD' named entity 'pathophysiological' named entity 'proinflammatory' named entity 'β-oxidation' named entity 'hypoxemia' named entity 'plasma' named entity 'respiratory function' named entity 'chemotactic' named entity 'respiratory failure' named entity 'epothilone' named entity 'ARDS' named entity 'NOX1' named entity 'PMNs' named entity 'antioxidant' named entity 'ARDS' named entity 'cell surface receptors' named entity 'calmodulin' named entity 'acute lung injury' named entity 'endothelial cells' named entity 'ROS' named entity 'Integrins' named entity 'CXCL1' named entity 'animal model' named entity 'redox' named entity 'redox potential' named entity 'antioxidant'

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