About: Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study

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About: Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study
Creator	Chen, Xiaorong Lu, Yunfei Chen, Liang Wang, Qiang Xu, Qingnian Yang, Zongguo
source	PMC
abstract	OBJECTIVE: The present study aimed to analyze clinical features and factors associated with treatment outcomes of H7N9 influenza A virus infection. METHODS: The clinical progress in 18 H7N9-infected patients was monitored and recorded. The clinical features of H7N9 infection were noted and factors associated with treatment outcomes were analyzed by univariate analyses. RESULTS: The average ages of patients in recovered and critical conditions were 67.0±10.83 years and 72.75±12.0 years, respectively. Renal insufficiency developed more frequently in critically ill patients (P = 0.023). The duration of traditional Chinese medicine (TCM) therapy was longer in recovered patients than in critically ill patients (P = 0.01). Laboratory tests showed that levels of C-reactive protein, serum creatinine, and myoglobin were significantly higher in critically ill patients than in recovered patients (P = 0.011, 0.04, and 0.016, respectively). Meanwhile, levels of all T cell subsets examined including total CD3(+), CD4(+), CD8(+), and CD45(+) T cells were lower in critically ill patients than in recovered patients (P = 0.033, 0.059, 0.015, and 0.039, respectively). Logistic regression analysis demonstrated that C-reactive protein level, myoglobin level and TCM therapy duration were likely associated with treatment outcomes of H7N9 infection (P = 0.032, 0.041 and 0.017, respectively). CONCLUSION: Elderly people may have increased risk for H7N9 virus infection. T cell-mediated responses play an important role in defense against the H7N9 virus. C-reactive protein level, myoglobin level and TCM duration may be associated with treatment outcomes of H7N9 infection.
has issue date	2013-09-17(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0073362
bibo:pmid	24069191
has license	cc-by
sha1sum (hex)	062a18fe6bcaad19bd60d8b47d3287079a915545
schema:url	https://doi.org/10.1371/journal.pone.0073362
resource representing a document's title	Clinical Features and Factors Associated with Outcomes of Patients Infected with a Novel Influenza A (H7N9) Virus: A Preliminary Study
has PubMed Central identifier	PMC3775774
has PubMed identifier	24069191
schema:publication	PLoS One
resource representing a document's body	covid:062a18fe6bcaad19bd60d8b47d3287079a915545#body_text
is schema:about of	named entity 'INFLUENZA A' named entity 'INFLUENZA A VIRUS INFECTION' covid:arg/062a18fe6bcaad19bd60d8b47d3287079a915545 named entity 'OUTCOMES' named entity 'VIRUS' named entity 'NOVEL' named entity 'H7N9 INFLUENZA' named entity 'CLINICAL FEATURES' named entity 'PRELIMINARY STUDY' named entity 'PATIENTS' named entity 'INFECTED' named entity 'ASSOCIATED WITH' named entity 'ASSOCIATED WITH' named entity 'TREATMENT OUTCOMES' named entity 'PRESENT' named entity 'CLINICAL FEATURES' named entity 'STUDY' named entity 'OBJECTIVE' named entity 'infection' named entity 'treatment outcomes' named entity 'influenza A virus' named entity 'epidemic' named entity 'seasonal influenza' named entity 'anti-influenza' named entity 'H7N9' named entity 'poultry' named entity 'medical examinations' named entity 'H1N1' named entity 'Chinese medicines' named entity 'quarantine' named entity 'C-reactive protein' named entity 'H7N9' named entity 'antibiotics' named entity 'sputum' named entity 'H7N9' named entity 'H7N9' named entity 'Shanghai' named entity 'laboratory tests' named entity 'H7N9' named entity 'viruses' named entity 'fever' named entity 'China' named entity 'poultry' named entity 'Fisher's exact test' named entity 'Beijing' named entity 'cough' named entity 'oseltamivir' named entity 'viral RNA' named entity 'viruses' named entity 'lower respiratory tract' named entity 'H7N9' named entity 'infection' named entity 'acute respiratory distress syndrome' named entity 'successful treatment' named entity 'logistic regression' named entity 'reverse transcription polymerase chain reaction' named entity 'diabetes' named entity 'antiviral drugs' named entity 'TCM' named entity 'total bilirubin' named entity 'critically ill' named entity 'CD3' named entity 'fatigue' named entity 'National Health and Family Planning Commission' named entity 'diabetes' named entity 'epidemiological' named entity 'mmol/l' named entity 'Asia' named entity 'zanamivir' named entity 'neurological condition' named entity 'hemoptysis' named entity 'univariate analysis' named entity 'informed consent' named entity 'oseltamivir' named entity 'glucocorticoid' named entity 'myoglobin'

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