About: Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model

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About: Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model
Creator	Schwarz, Tobias Collie, David Del-Pozo, Jorge Howard, Lynsey Kay, Elaine Lawrence, Jessica Mclachlan, Gerry Mclean, Alec Murchison, John Parys, Magdalena Smith, Sionagh Wright, Steven
Source	PMC
abstract	Methods to protect against radiation-induced lung injury (RILI) will facilitate the development of more effective radio-therapeutic protocols for lung cancer and may provide the means to protect the wider population in the event of a deliberate or accidental nuclear or radiological event. We hypothesised that supplementing lipid membranes through nebulization of synthetic lamellar lipids would mitigate RILI. Following pre-treatment with either nebulised lamellar lipids or saline, anaesthetised sheep were prescribed fractionated radiotherapy (30 Gray (Gy) total dose in five 6 Gy fractions at 3–4 days intervals) to a defined unilateral lung volume. Gross pathology in radio-exposed lung 37 days after the first radiation treatment was consistent between treatment groups and consisted of deep red congestion evident on the pleural surface and firmness on palpation. Consistent histopathological features in radio-exposed lung were subpleural, periarteriolar and peribronchial intra-alveolar oedema, alveolar fibrosis, interstitial pneumonia and type II pneumocyte hyperplasia. The synthetic lamellar lipids abrogated radiation-induced alveolar fibrosis and reduced alpha-smooth muscle actin (ASMA) expression in radio-exposed lung compared to saline treated sheep. Administration of synthetic lamellar lipids was also associated with an increased number of cells expressing dendritic cell-lysosomal associated membrane protein throughout the lung.
has issue date	2018-09-06(xsd:dateTime)
bibo:doi	10.1038/s41598-018-31559-3
bibo:pmid	30190567
has license	cc-by
sha1sum (hex)	05de65a45721a53c9704160d40571cce2cf1e866
schema:url	https://doi.org/10.1038/s41598-018-31559-3
resource representing a document's title	Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model
has PubMed Central identifier	PMC6127301
has PubMed identifier	30190567
schema:publication	Sci Rep
resource representing a document's body	covid:05de65a45721a53c9704160d40571cce2cf1e866#body_text
is schema:about of	named entity 'FIRMNESS' named entity 'UNILATERAL LUNG' named entity 'FEATURES' named entity 'MEMBRANE PROTEIN' named entity 'ASSOCIATED' named entity 'EXPOSED' named entity 'DEEP' named entity 'GRAY' named entity 'SALINE' named entity 'PROTOCOLS' named entity 'ALVEOLAR' named entity 'SUBPLEURAL' named entity 'alveolar' named entity 'interstitial pneumonia' named entity 'nebulization' named entity 'fibrosis' named entity 'membrane protein' named entity 'subpleural' named entity 'radiation treatment' named entity 'pleural' named entity 'saline' named entity 'lipids' named entity 'palpation' named entity '37 days' named entity 'lung' named entity 'anaesthetised' named entity 'Heatmap' named entity 'hyperplasia' named entity 'TGFbeta' named entity 'ImageJ' named entity 'Sheep' named entity 'Alveolar' named entity 'Qiagen' named entity 'interstitial pneumonia' named entity 'collagen' named entity 'staining' named entity 'lung tissue' named entity 'contralateral' named entity 'mesenchymal' named entity 'Histopathology' named entity 'cytoplasm' named entity 'lung fibrosis' named entity 'PTV' named entity 'pathology' named entity 'lungs' named entity 'interstitium' named entity 'contralateral' named entity 'nucleus' named entity 'radiation exposure' named entity 'maedi' named entity 'macrophages' named entity 'TGF-β' named entity 'fibrosis' named entity 'ground substance' named entity 'pathologist' named entity 'macrophages' named entity 'statistically significant' named entity 'fibrosis' named entity 'TGF-β1' named entity 'type II pneumocyte' named entity 'visna virus' named entity 'smooth muscle cells' named entity 'scavenges' named entity 'medical waste' named entity 'BALF' named entity 'membrane protein' named entity 'hyperplasia' named entity 'necropsy' named entity 'interstitium' named entity 'type II pneumocyte'

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