About: Genetic Variation of Multiple Serotypes of Enteroviruses Associated with Hand, Foot and Mouth Disease in Southern China

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About: Genetic Variation of Multiple Serotypes of Enteroviruses Associated with Hand, Foot and Mouth Disease in Southern China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic Variation of Multiple Serotypes of Enteroviruses Associated with Hand, Foot and Mouth Disease in Southern China
Creator	He, Min Wang, Lili Liu, Ping Yu, Hongjie Cui, Jie Zou, Gang Hong, Thi Lam, Yuk Tsan, Tommy Anh, To Le Van Tan, • Liao, • Luo, • Nguyen, • Qiu, Qi Rogier Van Doorn, • Xiaoman, • Yu, Shuanbao Zhou, Yonghong
Source	PMC
abstract	Enteroviruses (EVs) species A are a major public health issue in the Asia–Pacific region and cause frequent epidemics of hand, foot and mouth disease (HFMD) in China. Mild infections are common in children; however, HFMD can also cause severe illness that affects the central nervous system. To molecularly characterize EVs, a prospective HFMD virological surveillance program was performed in China between 2013 and 2016. Throat swabs, rectal swabs and stool samples were collected from suspected HFMD patients at participating hospitals. EVs were detected using generic real-time and nested reverse transcription-polymerase chain reactions (RT-PCRs). Then, the complete VP1 regions of enterovirus A71 (EV-A71), coxsackievirus A16 (CVA16) and CVA6 were sequenced to analyze amino acid changes and construct a viral molecular phylogeny. Of the 2836 enrolled HFMD patients, 2,517 (89%) were EV positive. The most frequently detected EVs were CVA16 (32.5%, 819), CVA6 (31.2%, 785), and EV-A71 (20.4%, 514). The subgenogroups CVA16_B1b, CVA6_D3a and EV-A71_C4a were predominant in China and recombination was not observed in the VP1 region. Sequence analysis revealed amino acid variations at the 30, 29 and 44 positions in the VP1 region of EV-A71, CVA16 and CVA6 (compared to the respective prototype strains BrCr, G10 and Gdula), respectively. Furthermore, in 21 of 24 (87.5%) identified EV-A71 samples, a known amino acid substitution (D31N) that may enhance neurovirulence was detected. Our study provides insights about the genetic characteristics of common HFMD-associated EVs. However, the emergence and virulence of the described mutations require further investigation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12250-020-00266-7) contains supplementary material, which is available to authorized users.
has issue date	2020-07-28(xsd:dateTime)
bibo:doi	10.1007/s12250-020-00266-7
has license	no-cc
sha1sum (hex)	05b1e1b43128d87513528d332f7ffe8a55b26cd4
schema:url	https://doi.org/10.1007/s12250-020-00266-7
resource representing a document's title	Genetic Variation of Multiple Serotypes of Enteroviruses Associated with Hand, Foot and Mouth Disease in Southern China
has PubMed Central identifier	PMC7385209
schema:publication	Virol Sin
resource representing a document's body	covid:05b1e1b43128d87513528d332f7ffe8a55b26cd4#body_text
is schema:about of	named entity 'identified' named entity 'EVs' named entity 'region' named entity 'molecularly' named entity 'A71' named entity 'common' named entity 'G10' named entity 'surveillance' named entity 'substitution' named entity 'Southern China' named entity 'HAND' named entity 'MUTATIONS' named entity 'CHILDREN' named entity 'ENTEROVIRUSES' named entity 'patients' named entity 'coxsackievirus' named entity 'EVs' named entity 'performed' named entity 'insights' named entity 'mouth' named entity 'reverse' named entity 'construct' named entity 'real-time' named entity 'acid' named entity 'patients' named entity 'participating' named entity 'China' named entity 'epidemics' named entity 'molecular phylogeny' named entity 'EV-A71' named entity 'HFMD' named entity 'central nervous' named entity 'recombination' named entity 'coxsackievirus A16' named entity 'China' named entity 'HFMD' named entity 'HFMD' named entity 'Genetic Variation' named entity 'EV-A71' named entity 'viruses' named entity 'serotypes' named entity 'EV-A71' named entity 'EV-A71' named entity 'MEME' named entity 'Asian' named entity 'multivalent vaccine' named entity 'EV-A71' named entity 'drug target' named entity 'PCR' named entity 'genotype' named entity 'Li Ka Shing' named entity 'annealing temperatures' named entity 'VP1' named entity 'VP1' named entity 'EV-A71' named entity '8/10' named entity 'genetic variation' named entity 'Enteroviruses' named entity 'VP1' named entity 'Europe' named entity 'genotype' named entity 'mainland China' named entity 'VP1' named entity 'Foster City' named entity 'capillary'

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