About: Genetic characteristics and polymorphisms in the chicken interferon-induced transmembrane protein (IFITM3) gene

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About: Genetic characteristics and polymorphisms in the chicken interferon-induced transmembrane protein (IFITM3) gene Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genetic characteristics and polymorphisms in the chicken interferon-induced transmembrane protein (IFITM3) gene
Creator	Jeong, Byung-Hoon Jeong, Min-Ju Kim, Yong-Chan
Source	Medline; PMC
abstract	The interferon-induced transmembrane protein 3 (IFITM3) gene is classified as a small interferon-stimulated gene and is associated with a broad spectrum of antiviral functions against several fatal enveloped viruses, including influenza A viruses (IAVs). The rs12252 single nucleotide polymorphism (SNP) of the IFITM3 gene in humans was associated with susceptibility to H1N1 influenza in a 2009 pandemic. In addition, overexpression of the IFITM3 protein potently inhibits the highly pathogenic avian influenza H5N1 virus in ducks and chickens. Although chickens are a major host of influenza viruses and the IFITM3 gene participates in the host antiviral system, studies on chicken IFITM3 gene are very rare. To investigate the genetic characteristics of the chicken IFITM3 gene, we performed direct sequencing and alignment in 108 Dekalb White and 72 Ross breeds. We also investigated the genotype and haplotype frequencies and linkage disequilibrium of the IFITM3 gene polymorphisms and evaluated whether the non-synonymous SNPs are deleterious. We found significantly different genotype, allele and haplotypes frequencies between two chicken breeds, Dekalb White and Ross. Furthermore, we compared and analyzed the promoter structure of the chicken IFITM3 gene with that of several species. We found that birds have a long C-terminal domain and inverted topology of the IFITM3 protein compared to mammals. We also identified fourteen genetic polymorphisms in the chicken IFITM3 gene. L100 M and N125H were predicted as ‘probably damaging’ and L100 M can alter the length of its conserved intracellular loop (CIL). Furthermore, chickens, but not mammals, contain CpG islands (CGIs) in this promoter region.
has issue date	2019-08-13(xsd:dateTime)
bibo:doi	10.1007/s11259-019-09762-y
bibo:pmid	31410631
has license	no-cc
sha1sum (hex)	059502a32c244618160be7085f4d9ac3d78296ed
schema:url	https://doi.org/10.1007/s11259-019-09762-y
resource representing a document's title	Genetic characteristics and polymorphisms in the chicken interferon-induced transmembrane protein (IFITM3) gene
has PubMed Central identifier	PMC7089262
has PubMed identifier	31410631
schema:publication	Vet Res Commun
resource representing a document's body	covid:059502a32c244618160be7085f4d9ac3d78296ed#body_text
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