About: iLIR@viral: A web resource for LIR motif-containing proteins in viruses

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About: iLIR@viral: A web resource for LIR motif-containing proteins in viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	iLIR@viral: A web resource for LIR motif-containing proteins in viruses
Creator	Charles, Hannah Jacomin, Anne-Claire Samavedam, Siva Nezis, Ioannis
Source	PMC
abstract	Macroautophagy/autophagy has been shown to mediate the selective lysosomal degradation of pathogenic bacteria and viruses (xenophagy), and to contribute to the activation of innate and adaptative immune responses. Autophagy can serve as an antiviral defense mechanism but also as a proviral process during infection. Atg8-family proteins play a central role in the autophagy process due to their ability to interact with components of the autophagy machinery as well as selective autophagy receptors and adaptor proteins. Such interactions are usually mediated through LC3-interacting region (LIR) motifs. So far, only one viral protein has been experimentally shown to have a functional LIR motif, leaving open a vast field for investigation. Here, we have developed the iLIR@viral database (http://ilir.uk/virus/) as a freely accessible web resource listing all the putative canonical LIR motifs identified in viral proteins. Additionally, we used a curated text-mining analysis of the literature to identify novel putative LIR motif-containing proteins (LIRCPs) in viruses. We anticipate that iLIR@viral will assist with elucidating the full complement of LIRCPs in viruses.
has issue date	2017-08-14(xsd:dateTime)
bibo:doi	10.1080/15548627.2017.1356978
bibo:pmid	28806134
has license	cc-by
sha1sum (hex)	05774f9508a8c3399ffb20e758f933ffadc40fbd
schema:url	https://doi.org/10.1080/15548627.2017.1356978
resource representing a document's title	iLIR@viral: A web resource for LIR motif-containing proteins in viruses
has PubMed Central identifier	PMC5640201
has PubMed identifier	28806134
schema:publication	Autophagy
resource representing a document's body	covid:05774f9508a8c3399ffb20e758f933ffadc40fbd#body_text
is schema:about of	named entity 'autophagy' named entity 'degradation' named entity 'Atg8' named entity 'http' named entity 'proviral' named entity 'complement' named entity 'MEDIATED' named entity 'TO INTERACT WITH' named entity 'AUTOPHAGY PROCESS' named entity 'FREELY' named entity 'PROTEIN ' named entity 'WEB' named entity 'NOVEL' named entity 'CURATED' named entity 'MEDIATE' named entity 'DEFENSE MECHANISM' named entity 'FAR' named entity 'USED' named entity 'LISTING' named entity 'INTERACTING' named entity 'DUE TO' named entity 'LEAVING' named entity 'ANTIVIRAL' named entity 'LIR' named entity 'IDENTIFIED' named entity 'ANALYSIS' named entity 'MOTIF' named entity 'VIRUSES' named entity 'TO IDENTIFY' named entity 'LC3' named entity 'MACHINERY' named entity 'TEXT-MINING' named entity 'LITERATURE' named entity 'ACCESSIBLE' named entity 'VIRUSES' named entity 'AUTOPHAGY' named entity 'INTERACTIONS' named entity 'FIELD' named entity 'THEIR' named entity 'ATG8' named entity 'REGION' named entity 'MACROAUTOPHAGY' named entity 'ASSIST' named entity 'INFECTION' named entity 'HAVE' named entity 'PATHOGENIC BACTERIA' named entity 'BUT' named entity 'WEB' named entity 'MOTIF' named entity 'LIR' named entity 'VIRAL PROTEIN' named entity 'PROCESS' named entity 'IMMUNE RESPONSES' named entity 'PROTEINS' named entity 'PLAY' named entity 'BACTERIA ' named entity 'COMPONENTS' named entity 'INVESTIGATION' named entity 'ROLE' named entity 'SERVE' named entity 'FUNCTIONAL' named entity 'DATABASE' named entity 'HERE' named entity 'USUALLY' named entity 'SELECTIVE AUTOPHAGY' named entity 'CENTRAL' named entity 'ACTIVATION' named entity 'FAMILY' named entity 'CONTRIBUTE ' named entity 'ADAPTOR' named entity 'PROTEINS' named entity 'RESOURCE' named entity 'CONTAINING' named entity 'CONTAINING' named entity 'OPEN' named entity 'VIRAL PROTEINS' named entity 'SELECTIVE' named entity 'COMPLEMENT'

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