About: Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators

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About: Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators
Creator	Sharma, Lokesh Schwarz, Benjamin Bosio, Catharine Ko, Albert Bermejo, Santos Casanovas Massana, Arnau Cruz, Charles Farhadian, Shelli Leighton, Ian Peng, Xiaohua Roberts, Lydia Team, Yale
Source	Medline; PMC
abstract	The COVID-19 pandemic has affected more than 10 million people worldwide with mortality exceeding half a million patients. Risk factors associated with severe disease and mortality include advanced age, hypertension, diabetes, and obesity.(1) Clear mechanistic understanding of how these comorbidities converge to enable severe infection is lacking. Notably each of these risk factors pathologically disrupts the lipidome and this disruption may be a unifying feature of severe COVID-19.(1–7) Here we provide the first in depth interrogation of lipidomic changes, including structural-lipids as well as the eicosanoids and docosanoids lipid mediators (LMs), that mark COVID-19 disease severity. Our data reveal that progression from moderate to severe disease is marked by a loss of specific immune regulatory LMs and increased pro-inflammatory species. Given the important immune regulatory role of LMs, these data provide mechanistic insight into the immune balance in COVID-19 and potential targets for therapy with currently approved pharmaceuticals.(8)
has issue date	2020-07-22(xsd:dateTime)
bibo:doi	10.21203/rs.3.rs-42999/v1
bibo:pmid	32743565
has license	cc-by
sha1sum (hex)	055339bc161a974aed1506b54bcfc07b499edc0a
schema:url	https://doi.org/10.21203/rs.3.rs-42999/v1
resource representing a document's title	Severe SARS-CoV-2 infection in humans is defined by a shift in the serum lipidome resulting in dysregulation of eicosanoid immune mediators
has PubMed Central identifier	PMC7386513
has PubMed identifier	32743565
schema:publication	Res Sq
resource representing a document's body	covid:055339bc161a974aed1506b54bcfc07b499edc0a#body_text
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