About: Association between detectable SARS‐COV‐2 RNA in anal swabs and disease severity in patients with coronavirus disease 2019

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About: Association between detectable SARS‐COV‐2 RNA in anal swabs and disease severity in patients with coronavirus disease 2019 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Association between detectable SARS‐COV‐2 RNA in anal swabs and disease severity in patients with coronavirus disease 2019
Creator	Tang, Xiaoping Li, Yueping Li, \| Cao, Yi Cai, Weiping Li, Linghua Lin, Weiyin Xie, Zhiwei Chunyan, \| Xu, \| Bd, Chen Bd, Li Bd, Ou Fengyu, \| Linghua, \| Liya, \| Md, Wen Phd, Hu Phd, Li Xiaoting, \|
Source	Medline; PMC
abstract	BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) RNA was found in the intestines and feces, but its clinical significance is not completely clear. We aim to characterize the longitudinal test results of SARS‐CoV‐2 RNA in anal swabs and to explore the association with disease severity. METHODS: We included laboratory‐confirmed coronavirus disease 2019 (COVID‐19) patients, who were hospitalized in Guangzhou Eighth People's Hospital and excluded those who had not received anal swabs for SARS‐COV‐2 RNA testing. Epidemiological, clinical, and laboratory data were obtained. Throat swabs and anal swabs were collected periodically for SARS‐COV‐2 RNA detection. RESULTS: Two hundred and seventeen eligible patients (median aged 50 years, 50.2% were females) were analyzed. 21.2% (46/217) of the patients were detected with SARS‐CoV‐2 RNA in anal swabs. The duration of viral RNA was longer, but the viral load was lower in anal swabs than throat swabs in the early stage of the disease. During a median follow‐up of 20 days, 30 (13.8%) patients were admitted to the intensive care unit (ICU) for high‐flow nasal cannula or higher‐level oxygen support measures to correct hypoxemia. Detectable viral RNA in anal swabs (adjusted hazard ratio [aHR], 2.50; 95% confidence interval [CI], 1.20‐5.24), increased C‐reactive protein (aHR, 3.14; 95% CI, 1.35‐7.32) and lymphocytopenia (aHR, 3.12; 95% CI, 1.46‐6.67) were independently associated with ICU admission. The cumulative incidence of ICU admission was higher among patients with detectable viral RNA in anal swabs (26.3% vs 10.7%, P = .006). CONCLUSION: Detectable SARS‐CoV‐2 RNA in the digestive tract was a potential warning indicator of severe disease.
has issue date	2020-07-27(xsd:dateTime)
bibo:doi	10.1002/jmv.26307
bibo:pmid	32672840
has license	no-cc
sha1sum (hex)	054164f4efa5fdde3ea357d068ca623f85429546
schema:url	https://doi.org/10.1002/jmv.26307
resource representing a document's title	Association between detectable SARS‐COV‐2 RNA in anal swabs and disease severity in patients with coronavirus disease 2019
has PubMed Central identifier	PMC7405477
has PubMed identifier	32672840
schema:publication	J Med Virol
resource representing a document's body	covid:054164f4efa5fdde3ea357d068ca623f85429546#body_text
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