About: Clinical characteristics of influenza virus-induced lower respiratory infection during the 2015 to 2016 season

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics of influenza virus-induced lower respiratory infection during the 2015 to 2016 season
Creator	Iwase, Noriyasu Koyama-Wakai, Chitose Miyairi, Isao Shoji, Kensuke Uda, Kazuhiro Fujisaki, Seiichiro Watanabe, Shinji Furuichi, Munehiro
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Influenza A(H1N1)pdm09 virus infections often manifest severe respiratory symptoms, particularly in patients with a past history of allergic disease. Most of these findings were reported during the 2009 pandemic. The purpose of this study was to detail the clinical characteristics of influenza virus-induced lower respiratory infection (LRI) during the A(H1N1)pdm09-predominant 2015–2016 season. METHODS: We retrospectively reviewed the clinical characteristics of influenza-induced LRI cases in children admitted to a tertiary children's hospital. Molecular diagnostic evaluation was performed on samples obtained from the most severe cases. RESULTS: We identified 66 patients with influenza-associated hospitalization and included 21 patients with influenza virus-induced LRI for analyses. Twelve patients (57%) were admitted to the pediatric intensive care unit, seven (33%) required mechanical ventilation, and three (14%) required extracorporeal membrane oxygenation. Plastic bronchitis (PB) was identified in six patients (29%), among whom a past medical history of asthma or food allergy were noted in all six patients. A past history of allergic disease was more common among patients with, than among those without, PB (p = 0.009). A(H1N1)pdm09 was detected from all the PB cases, and phylogenetic analyses of the hemagglutinin and neuraminidase genes demonstrated that this virus belonged to subclades 6B.1 and 6B.2. In the six PB cases, we found one patient with H275Y mutation in neuraminidase. CONCLUSION: Allergic disease was a risk factor for developing PB due to influenza A(H1N1)pdm09 infection during the 2015–16 season.
has issue date	2018-02-09(xsd:dateTime)
bibo:doi	10.1016/j.jiac.2018.01.002
bibo:pmid	29433792
has license	no-cc
sha1sum (hex)	050afa4cdede3553e25eb3d3ceccd18377cdec99
schema:url	https://doi.org/10.1016/j.jiac.2018.01.002
resource representing a document's title	Clinical characteristics of influenza virus-induced lower respiratory infection during the 2015 to 2016 season
has PubMed Central identifier	PMC7129183
has PubMed identifier	29433792
schema:publication	J Infect Chemother
resource representing a document's body	covid:050afa4cdede3553e25eb3d3ceccd18377cdec99#body_text
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