About: Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort

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About: Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort
Creator	Liang, Chen Siqueira, Marilda Oliveira, Maria Verjans, Georges Wakim, Linda Matos, Aline Garcia, Cristiana Martins, Jéssica
Source	PMC
abstract	Influenza is a major public health problem that causes acute respiratory infection in humans. Identification of host factors influencing in disease outcome is critical for recognition of individuals with increased risk. Investigations on the role of rs34481144A and rs12252C IFITM3 polymorphisms in influenza A(H1N1)pdm09 severity is not yet conclusively determined. This study aimed to evaluate such polymorphisms frequencies and IFITM3 levels in an infected Brazilian cohort of 314 influenza A(H1N1)pdm09 cases and its putative association with clinical, epidemiological and virological data. Individuals were clinically classified into mild, severe and fatal cases. IFITM3 polymorphisms were detected by specific Taqman probes in real time PCR reactions. IFITM3 levels were determined by quantitative real time PCR. Thus, the different clinical groups presented similar distribution of rs34481144 and rs12252 genotypes and allelic frequencies. There was no significant association between the polymorphisms with severity of disease by using distinct genetic models. Additionally, geographic distribution of mutants showed that rs34481144A allele was more predominant in Brazilian Southern region. In contrast, rs12252C allele presented similar frequencies in all regions. Individuals with the distinct rs34481144 and rs12252 genotypes showed similar levels of IFITM3 and viral load in their respiratory specimens. Furthermore, IFITM3 levels were comparable in the distinct clinical groups and were not correlated with influenza viral load in analyzed samples. Thereby, rs34481144A and rs12252C polymorphisms were not associated with severity or mortality of influenza A(H1N1)pdm09 infection nor with IFITM3 transcript levels and influenza viral load in upper respiratory tract samples in a Brazilian cohort.
has issue date	2020-07-10(xsd:dateTime)
bibo:doi	10.3389/fcimb.2020.00352
has license	cc-by
sha1sum (hex)	05018a1adfe02c379058d190dca5d5a632cb8161
schema:url	https://doi.org/10.3389/fcimb.2020.00352
resource representing a document's title	Investigation of Human IFITM3 Polymorphisms rs34481144A and rs12252C and Risk for Influenza A(H1N1)pdm09 Severity in a Brazilian Cohort
has PubMed Central identifier	PMC7366732
schema:publication	Front Cell Infect Microbiol
resource representing a document's body	covid:05018a1adfe02c379058d190dca5d5a632cb8161#body_text
is schema:about of	named entity 'cases' named entity 'levels' named entity 'infected' named entity 'influencing' named entity 'There' named entity 'levels' named entity 'Individuals' named entity 'INFECTION' named entity 'CLASSIFIED' named entity 'ROLE' named entity 'BRAZILIAN' named entity 'SOUTHERN REGION' named entity 'INFLUENZA A' named entity 'UPPER RESPIRATORY TRACT' named entity 'QUANTITATIVE REAL TIME PCR' named entity 'STUDY' named entity 'IFITM3' named entity 'ACUTE RESPIRATORY INFECTION' named entity 'MUTANTS' named entity 'DIFFERENT' named entity 'ASSOCIATED WITH' named entity 'INCREASED RISK' named entity 'influenza A' named entity 'acute respiratory infection' named entity 'polymorphisms' named entity 'predominant' named entity 'Brazilian' named entity 'allelic frequencies' named entity 'specific' named entity 'levels' named entity 'humans' named entity 'Investigations' named entity 'epidemiological' named entity 'severe' named entity 'disease outcome' named entity 'IFITM3' named entity 'A(H1N1)pdm09' named entity 'acute respiratory infection' named entity 'polymorphisms' named entity 'influenza' named entity 'polymorphisms' named entity 'polymorphisms' named entity 'polymorphisms' named entity 'influenza' named entity 'IFITM3' named entity 'biomarker' named entity 'real-time RT-PCR' named entity 'DCs' named entity 'ubiquitination' named entity 'WHO' named entity 'Influenza' named entity 'chi-square test' named entity 'infection' named entity 'polymorphism' named entity 'influenza' named entity 'cytosol' named entity 'IFITM3' named entity 'Influenza' named entity 'interferon' named entity 'JAK/STAT pathway' named entity 'severe acute respiratory infection' named entity 'influenza' named entity 'neurologic disorders' named entity 'influenza infection' named entity 'host factors' named entity 'melting curve analysis' named entity 'genotype' named entity 'N-terminal region' named entity 'genotype' named entity 'dyspnea' named entity 'lymph nodes' named entity 'SARI' named entity 'influenza infection' named entity 'influenza' named entity 'pathogen' named entity 'evolutionary process'

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