About: Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants

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About: Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants
Creator	Avadhanula, Vasanthi Tapia, Lorena Espinosa, Yazmín Piedra, Pedro Torres, Juan Farfán, Mauricio Martín, Camila Torres, Alejandro
Source	Medline; PMC
abstract	The clinical impact of viral factors (types and viral loads) during respiratory syncytial virus (RSV) infection is still controversial, especially regarding newly described genotypes. In this study, infants with RSV bronchiolitis were recruited to describe the association of these viral factors with severity of infection. RSV antigenic types, genotypes, and viral loads were determined from hospitalized patients at Hospital Roberto del Río, Santiago, Chile. Cases were characterized by demographic and clinical information, including days of lower respiratory symptoms and severity. A total of 86 patients were included: 49 moderate and 37 severe cases. During 2013, RSV-A was dominant (86%). RSV-B predominated in 2014 (92%). Phylogenetic analyses revealed circulation of GA2, Buenos Aires (BA), and Ontario (ON) genotypes. No association was observed between severity of infection and RSV group (p = 0.69) or genotype (p = 0.87). After a clinical categorization of duration of illness, higher RSV genomic loads were detected in infants evaluated earlier in their disease (p < 0.001) and also in infants evaluated later, but coursing a more severe infection (p = 0.04). Although types and genotypes did not associate with severity in our children, higher RSV genomic loads and delayed viral clearance in severe patients define a group that might benefit from new antiviral therapies.
has issue date	2017-03-21(xsd:dateTime)
bibo:doi	10.3390/ijms18030654
bibo:pmid	28335547
has license	cc-by
sha1sum (hex)	04d774680876efd10e478ed5f2ef7a7a2e860acf
schema:url	https://doi.org/10.3390/ijms18030654
resource representing a document's title	Genomic Loads and Genotypes of Respiratory Syncytial Virus: Viral Factors during Lower Respiratory Tract Infection in Chilean Hospitalized Infants
has PubMed Central identifier	PMC5372666
has PubMed identifier	28335547
schema:publication	Int J Mol Sci
resource representing a document's body	covid:04d774680876efd10e478ed5f2ef7a7a2e860acf#body_text
is schema:about of	named entity 'GENOTYPES' named entity 'GENOMIC' named entity 'BUT' named entity 'ADO' named entity 'MODERATE' named entity 'CLINICAL' named entity 'INFANTS' named entity 'LOWER' named entity 'CHARACTERIZED' named entity 'VIRAL CLEARANCE' named entity 'DETERMINED' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'DETECTED' named entity 'REVEALED' named entity 'OBSERVED' named entity 'ONTARIO' named entity 'GENOTYPE' named entity 'TOTAL' named entity 'THEIR' named entity 'VIRAL' named entity 'SEVERE' named entity 'LATER' named entity 'IMPACT' named entity 'BUENOS AIRES' named entity 'THERAPIES' named entity 'INFECTION' named entity 'DESCRIBED' named entity 'DAYS' named entity 'DOMINANT' named entity 'GENOMIC' named entity 'SANTIAGO' named entity 'ANTIVIRAL' named entity 'WITH SEVERITY' named entity 'PREDOMINATED' named entity 'ASSOCIATE' named entity 'CATEGORIZATION' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity '28P' named entity 'STUDY' named entity 'DEL' named entity 'INCLUDING' named entity 'CIRCULATION' named entity 'CHILEAN' named entity 'DISEASE' named entity 'DELAYED' named entity 'CLINICAL INFORMATION' named entity 'TO DESCRIBE' named entity 'CASES' named entity 'PATIENTS' named entity 'VIRAL' named entity 'HOSPITALIZED' named entity 'INFANTS' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'TYPES' named entity 'HIGHER' named entity 'HOSPITALIZED PATIENTS' named entity 'RESPIRATORY SYMPTOMS' named entity 'OUR' named entity 'THESE' named entity '0.04' named entity 'NEW' named entity 'BENEFIT' named entity 'DEMOGRAPHIC' named entity 'NEWLY' named entity 'DURATION OF ILLNESS' named entity 'A GROUP' named entity '0.001' named entity 'CHILDREN' named entity 'CHILE' named entity 'ASSOCIATION' named entity '2886' named entity 'EARLIER' named entity 'SEVERE INFECTION' named entity 'SEVERITY'

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