About: Human bocavirus: Current knowledge and future challenges

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About: Human bocavirus: Current knowledge and future challenges Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human bocavirus: Current knowledge and future challenges
Creator	Bagordo, Francesco De Donno, Antonella De Giorgi, Mattia Guido, Marcello Romano, Alessandro Serio, Francesca Verri, Tiziano Zizza, Antonella Tumolo, Maria De, Serio Donno, De Mr, Tumolo
Source	Medline; PMC
abstract	Human bocavirus (HBoV) is a parvovirus isolated about a decade ago and found worldwide in both respiratory samples, mainly from early life and children of 6-24 mo of age with acute respiratory infection, and in stool samples, from patients with gastroenteritis. Since then, other viruses related to the first HBoV isolate (HBoV1), namely HBoV2, HBoV3 and HBoV4, have been detected principally in human faeces. HBoVs are small non-enveloped single-stranded DNA viruses of about 5300 nucleotides, consisting of three open reading frames encoding the first two the non-structural protein 1 (NS1) and nuclear phosphoprotein (NP1) and the third the viral capsid proteins 1 and 2 (VP1 and VP2). HBoV pathogenicity remains to be fully clarified mainly due to the lack of animal models for the difficulties in replicating the virus in in vitro cell cultures, and the fact that HBoV infection is frequently accompanied by at least another viral and/or bacterial respiratory and/or gastroenteric pathogen infection. Current diagnostic methods to support HBoV detection include polymerase chain reaction, real-time PCR, enzyme-linked immunosorbent assay and enzyme immunoassay using recombinant VP2 or virus-like particle capsid proteins, although sequence-independent amplification techniques combined with next-generation sequencing platforms promise rapid and simultaneous detection of the pathogens in the future. This review presents the current knowledge on HBoV genotypes with emphasis on taxonomy, phylogenetic relationship and genomic analysis, biology, epidemiology, pathogenesis and diagnostic methods. The emerging discussion on HBoVs as true pathogen or innocent bystander is also emphasized.
has issue date	2016-10-21(xsd:dateTime)
bibo:doi	10.3748/wjg.v22.i39.8684
bibo:pmid	27818586
has license	cc-by-nc
sha1sum (hex)	046b480f92a27f809d67c98c77752037f3342d2a
schema:url	https://doi.org/10.3748/wjg.v22.i39.8684
resource representing a document's title	Human bocavirus: Current knowledge and future challenges
has PubMed Central identifier	PMC5075545
has PubMed identifier	27818586
schema:publication	World J Gastroenterol
resource representing a document's body	covid:046b480f92a27f809d67c98c77752037f3342d2a#body_text
is schema:about of	named entity 'TRUE' named entity 'STOOL' named entity 'NEW' named entity 'BIOLOGY' named entity 'RELATIONSHIPS' named entity 'DETECTION' named entity 'VIRUSES' named entity 'ETC.' named entity 'HUMAN BOCAVIRUS INFECTION' named entity 'SUPPORT' named entity 'DETECTED' named entity 'PASSENGERS' named entity 'UNDERSTOOD' named entity 'HUMAN BOCAVIRUS' named entity 'COMPREHENSION' named entity 'GASTROENTERITIS' named entity 'INTERACTION' named entity 'Despite' named entity 'respiratory tract' named entity 'support' named entity 'HUMAN BOCAVIRUS' named entity 'PATHOGENS' named entity 'MECHANISMS' named entity 'TOOLS' named entity 'MOLECULAR' named entity 'CHALLENGES' named entity 'FUTURE' named entity 'CURRENT' named entity 'KNOWLEDGE' named entity 'CLARIFY' named entity '28I' named entity 'RESEARCH' named entity 'WORLDWIDE' named entity 'NECESSARY' named entity 'POORLY' named entity 'EPIDEMIOLOGY' named entity 'THESE' named entity 'ASSOCIATION' named entity 'DIAGNOSTIC' named entity 'FOUND' named entity 'ASSOCIATED WITH' named entity 'DEVELOPMENT' named entity 'OCCURRENCE' named entity 'TAXONOMY' named entity 'TYPE' named entity 'RESPIRATORY TRACT' named entity 'HUMAN CELLS' named entity 'worldwide' named entity 'clarify' named entity 'future' named entity 'phylogenetic' named entity 'gastroenteritis' named entity 'viruses' named entity 'respiratory tract' named entity 'HBoV' named entity 'host-range' named entity 'serum' named entity 'phylogenetic analysis' named entity 'RT-PCR' named entity 'Beijing' named entity 'recombination' named entity 'humoral' named entity 'recombinant' named entity 'urine' named entity 'Th2' named entity 'acute respiratory infection' named entity 'virus species' named entity 'genotypes' named entity 'HEK293 cells' named entity 'RefSeq'

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